800,95 zł

Basic Principles of Drug Discovery and Development Elsevier Science Publishing Co Inc

Książki / Literatura obcojęzyczna

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, one that requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists,

Sklep: Libristo.pl

379,99 zł

Basic Principles Of Drug Discovery And Development

Książki Obcojęzyczne>Angielskie>Technology, engineering, agriculture>Industrial chemistry & manufacturing technologies>Industrial chemistr...

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Sklep: Gigant.pl

289,12 zł

Principles of Cancer Treatment and Anticancer Drug Development Springer Nature Switzerland AG

Książki / Literatura obcojęzyczna

This book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer, which includes Surgery, Radiation therapy, Chemotherapy, Targeted therapy and Immunotherapy. The efficiency of all these treatments is limited by the capacity of cancer cells to escape therapy. This book explains the mechanisms of anti-cancer drug resistance and strategies to overcome it. The discovery and development process of a new drug is detailed beginning with the identification and validation of a therapeutic target, the identification of an inhibitor of the target and its subsequent preclinical and clinical development until its approval by regulatory authorities. Particular emphasis has been given to specific aspects of the development process including lead generation and optimization, pharmacokinetics, ADME analysis, pharmacodynamics, toxicity and efficacy assessment, investigational new drug (IND) and new drug application (NDA) and the design of clinical trial and their phases. The book covers many aspects of modern personalized oncology and discusses economic aspects of our current system of developing new medicines and its impact on our societies and on future drug research. The author of this book, Dr. Link counts with more than 20 years of experience in biomedical research reflected in numerous publications, patents and key note and plenary presentations at international conferences. Interested readers, students and teachers should read this book as it provides a unique way to learn/teach about basic concepts in oncology and anti-cancer drug research.

Sklep: Libristo.pl

710,89 zł

Drug Discovery in Pancreatic Cancer Springer Verlag

Medycyna > English Division

Pancreatic cancer is the fourth leading cause of cancer death in the United States. Every year, about 33,700 people in the United States will be diagnosed with pancreatic cancer and over 32,000 patients will die from the disease. The median survival of patients with advanced pancreatic cancer is about 6-months. This dismal picture of pancreatic cancer is mainly due to the lack of early diagnosis and effective treatment for patients with advanced disease. To increase the survival rate of pancreatic cancer patients, better tumor markers for diagnosis and new molecular targets for drug development are desperately needed. A lot of effort has been made in searching for pancreatic cancer-causing genes or genes associated with progression of malignant behavior in pancreatic cancer. As a result, alterations in the expression of several cancer-related genes have been identified in pancreatic tumors. The identification and characterization of these cancer-related genes have significantly increased our understanding of pancreatic cancer development, but unfortunately the treatment of pancreatic cancer has not advanced as much in the past 20 years. Over the past decade, tremendous advances have been made in the field of cancer drug discovery, particularly, in the area of molecular and genetic models and technologies. Many of those advanced models and technologies have been applied to the drug discovery processes for pancreatic cancer. In this book, a team of experts will describe the latest development in the application of these models and technologies in pancreatic cancer. The authors include basic researchers as well as clinicians who work in the front-line of the war against pancreatic cancer and have the first-hand experience on these cutting-edge tools and techniques. The book can be divided into two general areas: model systems and genomics and proteomics tools. In recent years there have been a lot of advances in the model systems for pancreatic cancer, including the further characterization of normal and cancerous pancreatic cell lines, the establishment of transgenic mouse models that recapitulate the initiation and progression of human pancreatic cancer, the development of a new xenograft model system for the evaluation of novel agents, and the establishment of a zebrafish pancreatic cancer model. The first four chapters of the book will be devoted to these models. The advances in genomics and proteomics research have made a major impact in cancer drug discovery. A number of these -omics-based tools and techniques have been applied in the pancreatic cancer drug discovery. Chapters 5-9 of the book will discuss techniques for genome-wide examination of gene expression, copy number, methylation, function and regulation. Chapters 10-11 will discuss in situ techniques for studying chromosomal and gene copy number abnormalities as well protein expression changes in cancer samples. Chapters 12-14 will focus on techniques for global examination of protein expression levels in biospecimens obtained from pancreatic cancer patients. Cancer drug discovery has become more and more target-centric.

Sklep: Ksiazki-medyczne.eu

467,74 zł

Principles of Clinical Pharmacology Academic Press

Medycyna > English Division

This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists. Its features include: a unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy; an unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course; an instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study; wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry; expanded coverage of pharmacogenetics; expanded coverage of drug transporters and their role in interactions; inclusion of new material on enzyme induction mechanisms in chapters on drug metabolism and drug interactions; a new chapter on drug discovery that focuses on oncologic agents; and inclusion of therapeutic antibodies in chapter on biotechnology products. "Recent advances in pharmacogenetics, membrane transport, and biotechnology warrant a second edition of this excellent book...This will serve as an excellent text for an advanced course in principles of clinical pharmacology for graduate students, physicians, and PharmDs. Because of recent advances, the second edition is welcome." - Thomas L. Pazdernik, PhD, University of Kansas Medical Center, FOR DOODY'S (4 Stars)

Sklep: Ksiazki-medyczne.eu

474,50 zł

Principles of Clinical Pharmacology Academic Press

Zdrowie, medycyna

This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists. Its features include: a unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy; an unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course; an instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study; wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry; expanded coverage of pharmacogenetics; expanded coverage of drug transporters and their role in interactions; inclusion of new material on enzyme induction mechanisms in chapters on drug metabolism and drug interactions; a new chapter on drug discovery that focuses on oncologic agents; and inclusion of therapeutic antibodies in chapter on biotechnology products.

Sklep: Albertus.pl

375,95 zł

Principles of Clinical Pharmacology Academic Press

Medycyna > English Division

The rate of introduction of new pharmaceutical products has increased rapidly over the past decade, and details learned about a particular drug become obsolete as it is replaced by newer agents. "Principles of Clinical Pharmacology" focuses on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. The coverage of these principles in this book will be of particular benefit to individuals engaged either in the teaching or study of sound therapeutic technique or in the investigation of pharmacological agents. Key features include: the unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy; unusual cohesiveness of presentation that stems from author participation in an ongoing popular NIH course; instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study; and, wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry. "...this book fulfills the long-felt need for an updated publication in Clinical Pharmacology."-INDIAN JOURNAL OF PHARMACOLOGY (2003) "...this book is for the reader who wants a detailed in- depth understanding of clinical pharmacology."-E STREAMS (2003)

Sklep: Ksiazki-medyczne.eu

29,70 zł

DISCOVERY - 48 GODZIN Z BEAREM GRYLLSEM (2DVD) (Płyta DVD)

Książki & Multimedia > Filmy Video

Opis - Bear Grylls, ekspert w dziedzinie sztuki przetrwania i niekwestionowana gwiazda Discovery Channel powraca do akcji - tym razem w towarzystwie

Sklep: InBook.pl

992,50 zł

Vaccinology - Principles and Practice John Wiley and Sons Ltd

Książki / Literatura obcojęzyczna

Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe.§Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application§Includes evaluation of vaccine efficacy and safety§Details clinical trial design, including regulatory requirements§Discusses the emerging field of active cellular immunotherapy§Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.

Sklep: Libristo.pl

11,15 zł

Spalona Żywcem Wyd. Kieszonkowe - Souad

Książki & Multimedia > Książki

Opis - Pierwsze na świecie świadectwo ofiary zbrodni honorowej. Miała siedemnaście lat i zakochała się: zhańbiła rodzinę. Więc rodzina wydała na nią wyrok śmierci... Pokochała go pierwszą miłością. Myślała, że się z nią ożeni. Ale ukochany zniknął, a ona odkryła, że jest w ciąży. A w jej świecie to najcięższa zbrodnia... W zapomnianej przez Boga wiosce w Cisjordanii kobiety są warte mniej niż zwierzęta domowe. Tu mężczyzna jest panem życia i śmierci żony, córki, siostry. Brat może bezkarnie zabić siostrę, matka - córkę, kolejną bezużyteczną dziewczynkę, jaka się urodzi. Tu kobiecie odbiera się godność, a nawet życie zgodnie z odwiecznym obyczajem i uświęconą tradycją. A śmierć jest karą dla dziewczyny, która zhańbi rodzinę. Tak jak Souad. Wyrok wydaje jej ojciec. Szwagier dokonuje egzekucji. Oblewa Souad benzyną i podpala... SOUAD przeżyła - cudem, ale rodzina usiłowała zabić ją nawet w szpitalu. Na zawsze jednak pozostanie straszliwie okaleczona - na ciele i duszy. I wciąż musi się ukrywać; dopóki żyje, jej rodzinę okrywa hańba. Spalona żywcem, opublikowana pod pseudonimem szokująca opowieść o piekle, jakim było jej dzieciństwo i młodość, stała się międzynarodowym bestsellerem. Wydana w 37 w krajach książka przerywa tabu milczenia wobec istniejącej nadal w krajach muzułmańskich barbarzyńskiej tradycji. Nieludzkiego obyczaju, prawa mężczyzn, na mocy którego co najmniej pięć tysięcy kobiet pada co roku ofiarą zbrodni honorowej. Nazwa - Spalona Żywcem Wyd. Kieszonkowe Autor - Souad Oprawa - Miękka Wydawca - Amber Kod ISBN - 9788324159406 Kod EAN - 9788324159406 Wydanie - 1 Rok wydania - 2016 Tłumacz - 31182,maria rostworowska; Format - 110 x 175 x 14 Ilość stron - 224 Podatek VAT - 5% Premiera - 2016-06-23

Sklep: InBook.pl

291,33 zł

General Surgery John Wiley & Sons Inc

Książki / Literatura obcojęzyczna

Drug discovery and development is an expensive multi-disciplinary effort dependent on chemistry, structural biology, molecular and cell biology, pharmacology, physiology, statistics, computer sciences, engineering, medicine, law and business. It is a major challenge to incorporate all these fields into a single course, however it is also an opportunity to provide advanced students with a unifying context in which to apply knowledge from foundation courses. Rather than simply describing the drug discovery process, an essential goal of this text is to introduce the key decisions that are involved, the types of information needed to make these decisions, and the types of experiments used to obtain that information. In my teaching I have found that focusing on core concepts makes the subject accessible to a wider range of students and facilitates the integration of the knowledge into a context that is accessible and meaningful. This approach also serves to reinforce basic skills of research design and interpretation, and of data-driven decision-making skills relevant for a large number of potential learning and career directions. This book is intended to provide students with an understanding of the primary steps in the drug discovery and development process, key information needs associated with the decisions that govern the progression of projects from lab to clinic to market, and major research approaches used to provide information, support decision-making, and identify/prioritize candidate drug targets and candidate molecules. Along with a focus on the decision-making process, the text will emphasize the fundamental principles of science. Textboxes will highlight core concepts, techniques, and historic case examples, including examples from global infectious diseases such as malaria and sleeping sickness. End-of-chapter questions, a glossary and a math appendix will ensure that the text is accessible to upper-level undergraduates and graduate students.

Sklep: Libristo.pl

508,50 zł

Handbook of Medicinal Chemistry ROYAL SOCIETY OF CHEMISTRY

Książki / Literatura obcojęzyczna

Drug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry covers the past, present and future of the entire drug development process. Highlighting the recent successes and failures in drug discovery, the book will help readers to understand the factors governing modern drug discovery from the initial concept through to a marketed medicine. With chapters covering a wide range of topics from drug discovery processes and optimization, development of synthetic routes, pharmaceutical properties and computational biology, the handbook aims to help medicinal chemists to apply their academic understanding to every aspect of drug discovery. Each chapter includes expert advice to not only provide a rigorous understanding of the principles being discussed, but to provide useful hints and tips gained from within the pharmaceutical industry. This expertise, combined with project case studies, highlighting and discussing all areas of successful projects, make this an essential handbook for all those involved in pharmaceutical development.

Sklep: Libristo.pl

1195,90 zł

Orphan Drugs and Rare Diseases Royal Society Of Chemistry

Książki / Literatura obcojęzyczna

Orphan drugs are designated drug substances that are intended to treat rare or 'orphan' diseases. More than 7000 rare diseases are known that collectively affect some 6-7% of the developed world's population; however, individually, any single, rare disease may only affect a handful of people making them commercially unattractive for the biopharmaceutical industry to target. Ground breaking legislation, starting with the Orphan Drug Act that was passed in the US in 1983 to provide financial incentives for companies to develop orphan drugs, has sparked ever increasing interest from biopharmaceutical companies to tackle rare diseases. These developments have made rare diseases, and the orphan drugs that treat them, sufficiently attractive to pharmaceutical development and many pharmaceutical companies now have research units dedicated to this area of research. It is therefore timely to review the area of orphan drugs and some of the basic science, drug discovery and regulatory factors that underpin this important, and growing, area of biomedical research.Written by a combination of academic and industry experts working in the field, this text brings together expert authors in the regulatory, drug development, genetics, biochemistry, patient advocacy group, medicinal chemistry and commercial domains to create a unique and timely reference for all biomedical researchers interested in finding out more about orphan drugs and the rare diseases they treat. Providing an up-to-date monograph, this book covers the basic science, drug discovery and regulatory elements behind orphan drugs and will appeal to medicinal and pharmaceutical chemists, biochemists and anyone working within the fields of rare disease research and drug development or pharmaceuticals in industry or academia.

Sklep: Libristo.pl

866,57 zł

Neurotransmitter Enzymes Humana Press Inc.

Książki / Literatura obcojęzyczna

Techniques in the neurosciences are evolving rapidly. There are currently very few volumes dedicated to the methodology - ployed by neuroscrentists, and those that are available often seem either out of date or limited in scope. This series is about the methods most widely used by modern-day neuroscientrsts and is written by their colleagues who are practicing experts. Volume 1 will be useful to all neuroscientists since it concerns those procedures used routinely across the wrdest range of s- disciplines. Collecting these general techniques together in a single volume strikes us not only as a service, but will no doubt prove of exceptional utilitarian value as well. Volumes 2 and 3 describe all current procedures for the analyses of amines and their metabolites and of amino acids, respectively. These collections will clearly be of value to all neuroscientists working in or contemplating research in these fields. Similar reasons exist for Volume 4 on receptor binding techniques since experimental details are provided for all types of ligand-receptor binding, including chapters on general principles, drug discovery and development, and a most useful-appendix on computer programs for Scatchard, nonlinear, and competitive d- placement analyses. Volume 5 provides procedures for the asse- ment of enzymes involved in biogenic amme synthesis and catabolrsm. Volumes in the NEUROMETHODS series will be useful to neurochemists, -pharmacologists, -physiologists, -anatomists, psychopharmacologists, psychiatrists, neurologists, and chemists (organic, analyncal, pharmaceutical, medicinal); in fact, everyone involved in the neurosciences, both basic and clinical.

Sklep: Libristo.pl

1425,54 zł

New Polymeric Products

Książki / Literatura obcojęzyczna

New Polymeric Products: Fundamentals, Forming Methods and Applications mainly introduces some applications of polymer materials in new fields, including new products and new processing methods. For instance, the spherical tires using magnetic suspension show many intelligent characteristics; the nanofibrous catalyst layer provided fuel cell better performance; the new bacteriostatic mask will protect strongly from Covid-19. This book is rich in content and creativity. It introduces the development history, characteristics, and existing processing methods of polymer materials, comprehensive and systematic. It is also very suitable for interdisciplinary research related to the polymer. The latest achievements are introduced from the aspects of future travel, energy problems, special environment, lens materials and biomedicine, which are the most concerning areas of human society today. It introduces forming principles, methods, achievements, and development prospects from shallow to profound. It will benefit the researchers and new academic participants and broaden their vision. Further, it will bring creative ideas to the readers by elaborating on the brand-new polymeric products. In detail, the book is divided into six chapters. The first is the introduction, which is divided into three sections. The first section mainly introduces the development history and prospect of polymer materials. The second section introduces polymer materials, including new materials, characteristics, synthesis, naming, and functional. The third section introduces new processing and forming methods, which are introduced from three parts: plastic, rubber, and fiber according to different product types. The second chapter is rubber and spherical tires, which mainly introduces special rubber and its preparation, new bio-based rubber, tire production technology, spherical tire, and its 3D printing preparation method. The third chapter presents the energy-related polymer materials and forming processes, including fuel cell proton exchange membrane, fuel cell fiber catalyst layer, lithium electronic battery diaphragm materials, organic polymer electrode supercapacitors. The fourth chapter is the preparation of high-performance fibers, including carbon fibers, aramid fibers, ultra-high molecular weight polyethylene fibers, nanofibers and their production equipment, and high-performance impact-resistant airbags. The fifth chapter is the new lens materials and molding process, including resin lens materials and new contact lens materials and their preparation process. The sixth chapter is the biomedical application of polymer materials. It mainly introduces the material selection requirements, preparation methods and research results of artificial blood vessels, drug-carrying fibers of antituberculosis bacteria, wound dressing containing dragon's blood, fiber plaster, controlled-release fibers, and bacteriostatic masks. The content is novel and unique. Besides the brand-new products that just or will appear in the market, the whole book is composed of relevant research results of the author's team, general basic knowledge, and the latest research in relevant fields. Combining theory with practice, there are few such books on the market The content is selected and systematic. It introduces basic knowledge such as polymer development history, material characteristics and forming principles. The book arranges trivial contents such as polymer development history in tables to make it clearer and easier to understand. The rich pictures and tables give readers a clearer understanding of products, processing equipment and processes It is suitable for teaching materials full of scientific research ethics and humanistic care. The products introduced in the book are designed to solve the problems encountered in real life, such as energy issues. Combined with current events and adding an antibacterial mask, the new Coronavirus problem that all humanity needs to care about is introduced The cutting-edge chapters, such as the fuel cell assembly and future applications, such as the spherical tire, will ignite the academic reader's new ideas and promote the advancement of their research

Sklep: Libristo.pl

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