36,99 zł

The Clinical Causes Of Cancer Of The Breast And Its Prevention

Książki Obcojęzyczne>Nieprzypisane

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Sklep: Gigant.pl

371,50 zł

Infections & Human Cancer v.33 Cold Spring Harbor Laboratory Press

Zdrowie, medycyna

In the opening chapter of Infections and Human Cancer, Parkin and colleagues estimate that in 1990 there were 1.2 million new cases of cancer worldwide that were due to infectious agents. This figure accounts for about 15 percent of all cancers. These cases plus the sum of all neoplasms caused by tobacco account for the largest number of preventable cancers in the world. Infectious agents cause almost one fourth of all cancers in developing countries, a reflection of the high carrier rates in these regions for the four agents that cause 90 percent of cancers due to persistent infection: the hepatitis B and C viruses, the human papilloma viruses, and Helicobacter pylori. Microbial carcinogenesis is, for these reasons, a major public health problem. Its solution will require a huge investment of resources, almost all of it by industrialized countries. Moreover, neoplastic diseases evoked by persistent infection are no longer unusual in developed nations, as evidenced by the rising incidence of hepatocellular carcinoma in the United States, the high prevalence of papillomavirus infection among women, and the frequent occurrence of virus-induced cancers, such as Kaposi's sarcoma and B-cell lymphomas, in patients with AIDS. These facts make a compelling argument that physicians everywhere must understand the clinical implications of persistent infection with potentially oncogenic microbes, the advantages and limitations of screening for such infections and the cancers they cause, and the measures that are at hand or will be available to prevent the spread of these organisms. The two books reviewed here survey the epidemiologic evidence linking a variety of microbes to the causation of cancer, analyze the molecular mechanisms of microbial carcinogenesis, and discuss measures to thwart infection-associated cancer. The organisms under scrutiny include the human papillomaviruses, Epstein-Barr virus, human herpesvirus 8 (HHV-8, or Kaposi's sarcoma-associated herpesvirus), hepatitis B and C viruses, human T-cell leukemia virus, schistosoma, liver flukes, H. pylori, and intestinal bacteria. Each book features concise, timely expositions of various aspects of microbial oncogenesis, from descriptions of the culpable organisms to prevention by vaccination. Despite their similarities, these books differ in outlook and tone. For readers seeking a comprehensive review of the problems of infection-related cancer, both are worth examining. Infections and Human Cancer offers 15 surveys of the epidemiology, risk factors, and molecular mechanisms of carcinogenic microorganisms. The review of cancer in patients infected with the human immunodeficiency virus is excellent. A chapter on screening points out that the administration of hepatitis B immunoglobulin to newborns of infected mothers immediately after birth can reduce the carrier rate in children by as much as 90 percent. Presumably, the institution of national or worldwide programs of such prophylactic passive immunization against the hepatitis B virus will ultimately reduce the prevalence of hepatocellular carcinoma. In long-term carriers of the virus, screening with a combination of alpha-fetoprotein measurement and hepatic ultrasonography shows promise in detecting early, surgically resectable tumors. For hepatitis C, unfortunately, there is no effective means of prophylaxis, rendering moot the issue of screening until prevention is practical. Infections and Human Cancer concludes with a chapter on prophylactic and therapeutic vaccination against hepatitis B, human papillomaviruses, and H. pylori. Some of these vaccines are still in developmental stages; if they prove to be safe, effective, and economically feasible, they promise enormous benefits. Parsonnet leads off Microbes and Malignancy with a brief account of the history of the relation between infectious diseases and cancer. She places Leeuwenhoeck, who was born in 1632, in the 19th century and fails to mention Gross's seminal discovery of the mouse leukemia virus. However, she effectively relates how the history of cancer research was marred by false starts (notably Fibiger's mistaken claim that a nematode can cause stomach cancer, for which he was awarded the Nobel prize) and doubts that any organism could cause cancer (Rous had to wait more than 50 years before he was awarded the Nobel prize for his discovery of the chicken sarcoma virus). The first four chapters of Microbes and Malignancy deal with mechanisms of infection-induced cancer. Relman's review of chronic host-parasite interactions has a broad sweep, whereas the chapter on chronic inflammation and cancer focuses narrowly on the role of oxidative damage. Cohen reviews the evidence implicating cell proliferation in the pathogenesis of cancer but says little about DNA repair (defective DNA repair in ataxia-telangiectasia is well covered later by Karp and Blattner) or the chromosomal aberrations that are at least as essential to cell transformation as proliferation. In his excellent chapter on viral oncogenesis, Zur Hausen traces the evolution of cancer from infection with a carcinogenic human papillomavirus, through the loss of the cellular genes required to counteract the growth-promoting effects of papillomavirus oncoproteins, to the escape of the transformed cell from attack by the immune system. Microbes and Malignancy offers thorough reviews of the diseases caused by the Epstein-Barr virus, HHV-8, the hepatitis B and C viruses, H. pylori, and other relevant microbes. For readers interested in other microbial causes of cancer, there are informative reviews of the T-cell leukemia virus, schistosomes, and liver flukes. Robinson points out that, worldwide, only the number of lung cancers due to cigarette smoking exceeds the incidence of hepatocellular carcinoma due to hepatitis B virus. According to Parsonnet, about half the world's population harbors H. pylori, yet in only 1 percent does gastric cancer develop. Gastric lymphoma is even rarer, and it occasionally occurs simultaneously with gastric cancer. Infections and Human Cancer and Microbes and Malignancy are fascinating books, and like all good surveys of scientific matters, they raise profound questions for which there are no immediate answers. A thread running through both books is that despite its immense power to give us a close-up view of how cancer develops, molecular biology cannot show us the big picture. Until we find new ways of looking at the connections between microbes and cancer, we will remain, as Milton said in Comus, 'in the blind mazes of this tangled wood.'

Sklep: Albertus.pl

850,98 zł

Vitamin D Springer-Verlag New York Inc.

Książki / Literatura obcojęzyczna

In Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Second Edition, Volume 1, leading researchers provide a comprehensive, highly readable overview of the biological functions and clinical applications of vitamin D and its metabolites. Presented in a newly affordable softcover format this volume contains Parts IV through VII of the previously published hardcover text. Topics range from the most recent recommendations for vitamin D intake to new approaches for the treatment and prevention of vitamin D deficiency and the development of active vitamin D drugs to treat psoriasis and cancer. The book demonstrates the significant role that vitamin D has in maintaining good bone health and the prevention of osteoporosis, an important health problem for adults over the age of fifty. In addition, it authoritatively reviews the relationship between sunlight exposure, vitamin D, and increased risk of colon and breast cancer; how vitamin D is made in the skin; and the sequence of events that leads to its activation by the kidney. Also examined are the biological functions of 1,25-dihydrovitamin D3 on the intestine and bone, as well as other tissues, such as skin, the immune system, prostate, and breast, and vitamin D's molecular mechanism of action on the cell membrane and nucleus. Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Second Edition, Volume 1 is designed and organized not only to be an up-to-date review on the subject, but also to provide medical students, graduate students, health care professionals and even the lay public with a reference source for the most up-to-date information about the vitamin D deficiency pandemic and its clinical implications for health and disease.

Sklep: Libristo.pl

597,84 zł

Vitamin D Springer-Verlag New York Inc.

Książki / Literatura obcojęzyczna

In Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Second Edition, Volume 1 , leading researchers provide a comprehensive, highly readable overview of the biological functions and clinical applications of vitamin D and its metabolites. Presented in a newly affordable softcover format this volume contains Parts IV through VII of the previously published hardcover text. Topics range from the most recent recommendations for vitamin D intake to new approaches for the treatment and prevention of vitamin D deficiency and the development of active vitamin D drugs to treat psoriasis and cancer. The book demonstrates the significant role that vitamin D has in maintaining good bone health and the prevention of osteoporosis, an important health problem for adults over the age of fifty. In addition, it authoritatively reviews the relationship between sunlight exposure, vitamin D, and increased risk of colon and breast cancer; how vitamin D is made in the skin; and the sequence of events that leads to its activation by the kidney. Also examined are the biological functions of 1,25-dihydrovitamin D3 on the intestine and bone, as well as other tissues, such as skin, the immune system, prostate, and breast, and vitamin D's molecular mechanism of action on the cell membrane and nucleus. §Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Second Edition, Volume 2 is designed and organized not only to be an up-to-date review on the subject, but also to provide medical students, graduate students, health care professionals and even the lay public with a reference source for the most up-to-date information about the vitamin D deficiency pandemic and its clinical implications for health and disease.§

Sklep: Libristo.pl

553,80 zł

Recent Advances in Clinical Oncology Blackwell Science

Zdrowie, medycyna

The exchange of ideas and knowledge concerning cancer prevention and methods forpatient education is essential to giving patients all over the world access to the most up-to-date therapies. Cancer is the third leading cause of death in the United Arab Emirates, accounting for 12% of fatalities. Concerted efforts are now being made to heighten awareness with regard to prevention, screening, early diagnosis and multimodality therapy for advanced disease. Issues addressed in this volume include evidence-based oncology, molecular biology, diagnosis, staging and treatment encompassing chemotherapy, radiation therapy, surgery, novel experimental and therapeutic strategies, and palliative care. Specific topical sections relate to common disorders in the UAE such as breast, hematological, colorectal, pediatric, upper gastrointestinal, gynecological and endocrine malignancy.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Sklep: Albertus.pl

111,71 zł

Dr. Atkins' Vita-Nutrient Solution Simon & Schuster

Książki / Literatura obcojęzyczna

THE HEALING POWER OF NUTRITIONAL SUPPLEMENTS Long a champion of complementary medicine and nutritional therapy, Dr. Robert Atkins, author of the #1 best-seller Dr. Atkins' New Diet Revolution, presents the scientific basis for the use of vitamins, minerals, amino acids, herbs, and hormones in the treatment and prevention of many of the chronic illnesses that plague us today. These vita-nutrients harness the body's ability to heal itself, rather than resorting to conventional drugs and invasive procedures, and address the true causes of disease instead of temporarily alleviating symptoms, promoting longer-lasting and more effective healing. In this comprehensive guide, Dr. Atkins shares vital information on more than 120 supplements, including: * The specific restorative powers of each nutrient * How to determine the optimal dosage schedule * How to obtain supplements that are new to the market or are available only in limited supply * The formula for a basic foundation of vita-nutrients that almost everyone needs every day Best of all, Dr. Atkins shows you how to create a personalized program to help improve or regain your health by using combinations of nutritional supplements specifically designed to help cure or prevent more than fifty common medical conditions, including arthritis, cancer, diabetes, heart disease, or infections. Backed by cutting-edge scientific research, his recommendations are both safe and effective.

Sklep: Libristo.pl

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