Optimizing the "Drug-Like" Properties of Leads in Drug Discovery

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Drug-like Properties

Książki Obcojęzyczne>Angielskie>Mathematics & science>Biology, life sciences>Life sciences: general issues>XenobioticsKsiążki Obcojęzyc...

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Discovering and Developing Molecules with Optimal Drug-Like Properties

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Nanoscale Engineering of Biomaterials: Properties and Applications Springer Verlag, Singapore

Książki / Literatura obcojęzyczna

This book provides a comprehensive overview of the latest advances in a wide range of biomaterials for the development of smart and advanced functional materials. It discusses the fundamentals of bio-interfacial interactions and the surface engineering of emerging biomaterials like metals and alloys, polymers, ceramics, and composites/nanocomposites. In turn, the book addresses the latest techniques and approaches to engineering material surfaces/interfaces in, e.g., implants, tissue engineering, drug delivery, antifouling, and dentistry. Lastly, it summarizes various challenges in the design and development of novel biomaterials. Given its scope, it offers a valuable source of information for students, academics, physicians and particularly researchers from diverse disciplines such as material science and engineering, polymer engineering, biotechnology, bioengineering, chemistry, chemical engineering, nanotechnology, and biomedical engineering for various commercial and scientific applications.

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Drug Discovery Bundle Pack Academic Press

Nauka

Combining two essential Academic Press books, this bundle provides reference information for drug discovery researchers and professionals at a great price. Drug Like Properties provides drug discovery scientists and students with a practical understanding of property fundamentals and structure modification strategies that can be applied to improving drug leads. The Organic Chemistry of Drug Design and Drug Action represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules.

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Wpraw to w ruch. Proste mechanizmy dla wynalazców, majsterkowiczów i artystów - Dustyn Roberts

Książki & Multimedia > Książki

Opis - Podręcznik majsterkowicza! Każdy majsterkowicz marzy o zbudowaniu maszyny, która może być wprawiana w ruch. Koła zębate, przekładnie, napędy to kluczowe elementy, obok których żaden pasjonat majsterkowania nie przejdzie obojętnie! Jeżeli chcesz poznać skuteczne techniki ruchomego łączenia części, jeżeli chcesz zbudować maszynę wprawianą w ruch, to trafiłeś na rewelacyjną książkę, która wprowadzi Cię w świat mechanizmów. Sięgnij po nią i poznaj najczęściej stosowane materiały oraz dowiedz się, jak je łączyć i gdzie ich szukać. Na kolejnych stronach znajdziesz cenne informacje na temat mocowania różnych elementów oraz poznasz kluczowe pojęcia: siły, tarcia i momentu obrotowego. Uzbrojony w tę wiedzę, przystąpisz do poznawania źródeł mocy mechanicznej i elektrycznej oraz zbudujesz pojazd zasilany pułapką na myszy! Na sam koniec zobaczysz, jak korzystać z łożysk i sprzęgieł oraz nauczysz się łączyć proste maszyny w złożone układy. W tej unikalnej publikacji pokazano liczne projekty, których realizacja sprawi Ci mnóstwo frajdy. Książka ta musi znaleźć się na półce każdego szanującego się majsterkowicza! Sięgnij po tę książkę i: wybierz właściwe materiały do Twojego projektu poznaj połączenia rozłączne oraz nierozłączne opanuj techniki obliczania siły i momentu obrotowego wykorzystaj łożyska, sprzęgła, sprężyny i śruby zbuduj zaawansowaną maszynę Zbuduj wymarzoną maszynę! Zerknij na przykłady: - kliknij, by powiększyć: Dustyn Roberts - inżynier mechanik, nauczycielka. Założycielka firmy doradczej Dustyn Robots. Posiada szeroką wiedzę, zdobytą w trakcie studiów na uniwersytecie Carnegie Mellon, uniwersytecie Delaware oraz Politechnice Nowojorskiej. Nazwa - Wpraw to w ruch. Proste mechanizmy dla wynalazców, majsterkowiczów i artystów Oryginalny tytuł - Making Things Move DIY Mechanisms for Inventors, Hobbyists, and Artists Autor - Dustyn Roberts Oprawa - Miękka Wydawca - Helion Kod ISBN - 9788324698578 Kod EAN - 9788324698578 Rok wydania - 2015 Język - PL Tłumacz - Krzysztof Sawka Format - 170x230 Ilość stron - 344 Podatek VAT - 5% Premiera - 2015-03-12

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Traditional and Folk Herbal Medicine Astral International Pvt Ltd

Książki / Literatura obcojęzyczna

In the present volume of the book series "Traditional and Folk Herbal Medicine: Recent Researches- Vol. 2" an attempt has been made to cover the major topics on the subject. The book is written in a lucid style and includes nineteen review and research articles contributed by scientists from various countries across the globe and especially from Bangladesh, Brazil, China, Ethiopia, India, Malaysia, Portugal, South Africa and U.K. to quote a few amongst them and includes topics like- Prospects, Paradigms and Drawbacks of Current Research on Herbal Medicines; Artemisia annua: A Precious Traditional and Folk Antimalarial Medicinal Plant; Traditional and Folk Herbal Medicine in Czech Republic ; Preclinical Investigation of the Antineoplastic Activity of an Ayurvedic Rasayana Drug the Guduchi; Centella asiatica: A Natural Remedy for the Treatment of Disease; Orthosiphon aristatus: A Review of Traditional Uses, Phytochemical Profile, and Pharmacological Properties; Standardization, Pharmacological Evaluation and Safety Studies of Sitopaladi Churna; In vitro Antimicrobial and Antioxidant Potency of Two Nutraceutical Plants of Cucurbitaceae; Applying the Cultural Salience Index to Medicinal Plants Used by the Baixa dos Quelés quilombola Community; Fabaceae Family Medicinal Plants Used in Folk Medicinal Practices of Bangladesh for Treatment of Cancer; Anti-inflammatory Activity of the Hydroethanol Extract of Plantago erosa in Various Models of Inflammation; The Study on Chinese Patents upon Miao Ethnic Drug Cynanchum wilfordii (Maxim.) Hemsl and Bai/Yi Ethnic Drug Geranium strictipes R. Knuth; Cyclooxygenase Inhibitory, Anti-inflammatory and Anti-oxidant Effects of Wrightia tinctoria R.Br; Traditional Phytotherapy as Herbal Aphrodisiacs: A Recent Indian Perspective; Andrographis paniculata and its Major Diterpenoid- Andrographolide: Traditional Uses, Phytochemistry and Pharmacological Properties; Phytopharmacological Overview on Controversial Drug: Murva; Evaluation of Clinical Efficacy of Selected Hair Care Herbs in Ayurvedic Hair Oil for Treatment of Dandruff, Hair Fall and Stress; Biological and Functional Properties of Bee Products for Medicinal Purposes; Aloe vera: a Miracle Plant. The Editor and contributors have tried their best to bring out this book incorporating standard topics and up-to-date information on various aspects of Traditional and Folk herbal medicine and hope that this will stimulate interest and satisfy the need for further knowledge of academicians, researchers and scientists working on herbal medicine.

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Functionalized Conjugated Polyelectrolytes Springer-Verlag Berlin and Heidelberg GmbH & Co....

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Functionalized Conjugated Polyelectrolytes presents a comprehensive review of these polyelectrolytes and their biomedical applications. Basic aspects like molecular design and optoelectronic properties are covered in the first chapter. Emphasis is placed on the various applications including sensing (chemical and biological), disease diagnosis, cell imaging, drug/gene delivery and disease treatment. This book explores a multi-disciplinary topic of interest to researchers working in the fields of chemistry, materials, biology and medicine. It also offers an integrated perspective on both basic research and application issues. Functionalized conjugated polyelectrolyte materials, which have already drawn considerable interest, will become a major new direction for biomedicine development.§

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Tamarind Kernel Gum LAP LAMBERT Academic Publishing

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Natural gums are economical and easily available. Gums have been wildly used as tablet binders, emulgents and thickeners, in cosmetics and suspensions, as film-forming agents and transitional colloids. Polysaccharides are the choice of materials among the hydrophilic polymers used, because they are nontoxic and acceptable by regulating authorities. The various polysaccharides used in drug delivery applications are cellulose ethers, xanthan gum, locust bean gum, and guar gum. Another natural gum Tamarind kernel gum obtained from the seed kernel of Tamarindus indica, possesses properties like less density, broad pH tolerance, non-carcinogenicity, mucoadhesive nature, biocompatibility. Therefore, it can be used as a natural floating polymer in floating systems.

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Lesley Jacobs Solmonson - Gin REAKTION BOOKS

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Mother's Milk or Mother's Ruin; Dutch Courage or Cuckold's Comfort: the fanciful nicknames that gin has acquired only hint at its colourful story.§In Gin: A Global History, wine and spirits writer Lesley Jacobs Solmonson journeys into gin's past to reveal how the spirit has played both hero and villain throughout history. The tale begins with the aromatic juniper berry, whose medicinal properties have been used since antiquity. It was the Dutch who recognized juniper's more alcoholic possibilities, distilling it into the whiskey-like genever. This 'original gin' made its way to Britain where imitations laced with turpentine and other caustic fillers became the street drug of choice for poor eighteenth-century Londoners. Eventually, this deadly concoction was replaced by the sweetened Old Tom style and then by London Dry gin, whose popularity spread along with the British Empire.§While British society types and naval officers sipped their Gins and Tonic, American bartenders showcased both genever and English gins during the Golden Age of the Cocktail. On both sides of the Atlantic, as well as around the globe, London Dry won the popularity contest in classic drinks such as the dry Martini and the Gimlet. Today the juniper-based elixir has reasserted its importance, as the world of mixology once again embraces classic cocktails.§Gin: A Global History features many enticing recipes and images from the past and present of gin. The book will entice both cocktail aficionados and students of socio-political change, as it chronicles gin's evolution from humble berry to modern alcoholic marvel. You will never regard a martini in the same way again.

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