482,39 zł

Advances in Protein Chemistry and Structural Biology: Vol. 80 Academic Press

Medycyna > English Division

Structural genomics is the systematic determination of 3-dimensional structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large scale cloning, expression and purification. One main advantage of this approach is economy of scale. This title examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy. It looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission.

Sklep: Ksiazki-medyczne.eu

1915,43 zł

Plant Genetics and Molecular Biology Springer International Publishing AG

Książki / Literatura obcojęzyczna

This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science.Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification.In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

Sklep: Libristo.pl

559,80 zł

Application of Solution Protein Chemistry to Biotechnology CRC Press Inc.

Nauka

Relying upon his broad view of biotechnology, pioneering scientist, Roger Lundblad draws from both traditional protein science and proteomics to include a great deal of material not found in electronic format. He includes chapters on the use of classical protein chemistry in food, the protein and carbohydrate chemistry of adhesives, glues and sealants, protein chemistry and hydrogels, and the use of chemical modification to prepare protein therapeutics. While demonstrating current use and the development of biotech applications, Lundblad makes a point to separate what is truly new from that which has merely been renamed. Ultimately, he provides much time saving research on which others can build. One of the world's most respected protein researcher, Dr. Lundblad has authrored and edited several books for CRC Press including the "Biochemistry and Molecular Biology Compendium".

Sklep: Albertus.pl

562,91 zł

Protein Folding Springer, Berlin

Książki / Literatura obcojęzyczna

This volume provides comprehensive protocols on experimental and computational methods that are used to study probe protein folding reactions and mechanisms. Chapters divided into five parts detail protein engineering, protein chemistry, experimental approaches to investigate the thermodynamics and kinetics of protein folding transitions, probe protein folding at the single molecule, analysis and interpretation of computer simulations, procedures and tools for the prediction of protein folding properties. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Protein Folding: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field.

Sklep: Libristo.pl

4046,21 zł

Encyclopedia of Analytical Chemistry, Supplementary VS1-S3 John Wiley & Sons Inc

Książki / Literatura obcojęzyczna

The new 3-Volume Supplementary Set for Encyclopedia of Analytical Chemistry contains 95 new articles (published online in Encyclopedia of Analytical Chemistry (EAC) from 2008 - 2010), covering subjects which have achieved particular prominence and distinction since the print publication of EAC in 2000. The new 3 Volume Set includes advances in applications and theory ranging from mass spectrometry, atomic, infrared, Raman and X-ray spectroscopy, to nuclear magnetic resonance and imaging, nuclear methods, electrochemistry, and hyphenated techniques. Provides essential information required to analyze elements and compounds as well as structures in a wide variety of matrices for a range of applications, interpret the results and also gain a thorough knowledge of the theory and instrumentation utilized.Coverage of key advances includes: Proteomics and genomics Coverage of quantitative proteomics, electrochemical detection, dynamic light scattering, amyloids and protein aggregation measurements to low-cost, high-throughput gene sequencing Imaging technologies Coverage of major new medical and biological techniques including: ultrashort laser pulse medical imaging, quantitative imaging of membrane mechanics with molecular resolution, 3D neutron imaging, scanning near-field ultrasound holography, atomic force microscopy in nanocell biology, biomolecular interactions using nanopore force spectroscopy, scanning electrochemical microscopy and quadrupolar nuclei in biological systems Nanotechnology Expanded coverage of nanotechnology including scanning probe microscopy for imaging nanoparticles and nanocrystals, nanomaterials for electroanalysis, as well as scanning electrochemical microscopy, and scanning near-field ultrasound holography Other major advances There is also comprehensive coverage of advances in environmental monitoring, drinking water analysis, forensic science, electronic absorption and luminescence spectroscopy, infrared spectroscopy, atomic spectroscopy, nuclear magnetic resonance and electrochemistry; as well as specific coverage in pharmaceuticals and drugs, clinical chemistry, X-ray spectrometry, chemometrics, polymers and liquid chromatography Written at a level appropriate to allow a chemist (organic, polymer, inorganic, biochemist, molecular biologist), physicist or engineer to discover methodology for the analysis of most molecular and biological structures and materials.Find out more about EAC Online here: http://tiny.cc/eaconline

Sklep: Libristo.pl

428,99 zł

Molecular Dynamics Springer International Publishing AG

Książki / Literatura obcojęzyczna

This book describes the mathematical underpinnings of algorithms used for molecular dynamics simulation, including both deterministic and stochastic numerical methods. Molecular dynamics is one of the most versatile and powerful methods of modern computational science and engineering and is used widely in chemistry, physics, materials science and biology. Understanding the foundations of numerical methods means knowing how to select the best one for a given problem (from the wide range of techniques on offer) and how to create new, efficient methods to address particular challenges as they arise in complex applications.Aimed at a broad audience, this book presents the basic theory of Hamiltonian mechanics and stochastic differential equations, as well as topics including symplectic numerical methods, the handling of constraints and rigid bodies, the efficient treatment of Langevin dynamics, thermostats to control the molecular ensemble, multiple time-stepping, and the dissipative particle dynamics method.

Sklep: Libristo.pl

279,97 zł

Molecular Enzymology Springer-Verlag New York Inc.

Książki / Literatura obcojęzyczna

MOLECULAR ENZYMOLOGY, BECAUSE OF ITS CHEMICAL AND MATHEMATICAL content, is often regarded as a formidable and forbidding topic by undergraduates on a biology or biochemistry course, As a result of teaching enzymology to undergraduates for a number of years, we recognize the areas which appear to cause the most common difficulties in conceptual understanding. We feel that a book treating those areas by means of a logical approach carefully developed from basic principles fills a gap in the multiplicity of enzymology texts currently available. In writing this book we h;:lVe had in mind the needs of Honours Biochemistry students, in particular those who may take a special interest in enzymology. The text covers the main bulk of the material required in the second and third years of such courses. In addition, those taking courses in Biological Chemistry may well find the book to be of central interest. The book begins with a description of the fundamentals of catalysis, illustrating these with simple chemical reactions which may be supposed to serve as models of catalytic processes. Protein structure is discussed in terms of the fundamental forces which determine the shape and dynamic behaviour of protein molecules. The approach emphasizes those features thought to be most intimately involved in the catalytic function of enzyme molecules, and is illustrated with specific examples.

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659,23 zł

Tau Protein Humana Press Inc.

Książki / Literatura obcojęzyczna

This detailed volume gathers basic and advanced methods and protocols from in vitro assays and in vivo models to address the molecular and functional aspects of tau physiopathology. Divided into five parts that illustrate the underlying molecular mechanisms of Tau functions and dysfunctions in Alzheimer's disease and other dementia referred to as tauopathies, this volume discusses timely topics such as: conformational studies of native tau protein and investigation of its physiological function in microtubules binding and tubulin polymerization; in vitro methods of formation and detection of tau oligomers and PHF-like fibrils; characterization and in vitro introduction of post-translational modifications on tau proteins for further functional studies; analytical tools for the detection of tau proteins, their modifications and cellular interactions, and MAPT gene mutations in various biological samples; and cellular and in vivo models for the investigations of tau physiopathology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.§§Practical and cutting-edge, Tau Protein: Methods and Protocols is a valuable resource that addresses the most recent aspects of Alzheimer's disease research related to Tau protein and state-of-the-art experimental techniques. It targets a broad scientific audience including molecular biologists and biochemists, as well as all researchers interested in exploring the functions of tau proteins.§

Sklep: Libristo.pl

511,69 zł

Peptide and Protein Delivery APress

Medycyna > English Division

The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary/collaborative projects, "Peptide and Protein Delivery" addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. It discusses the most recent data, ideas and concepts. It presents case studies and an industrial perspective. It details information from the molecular level to bioprocessing. It is thought provoking, for the novice to the specialist. It is timely, for today's biopharmaceuticals market.

Sklep: Ksiazki-medyczne.eu

1099,18 zł

Protein Chromatography Springer, Berlin

Książki / Literatura obcojęzyczna

This third edition expands on the previous editions with updated and new chapters on protein chromatography. Chapters detail protein stability and storage, avoiding proteolysis, protein quantitation methods, generation and purification of recombinant proteins, recombinant antibody production, and the tagging of proteins. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Protein Chromatography: Methods and Protocols, Third Edition aims to provide commonly used methods and new approaches to help both new researchers and experts expand their knowledge.

Sklep: Libristo.pl

1680,20 zł

Protein Degradation Series 4 vols VCH

Nauka

This series of four topical volumes includes more than 50 contributions covering all aspects of the molecular biology and physiology of controlled protein breakdown in higher organisms via the ubiquitin-proteasome pathway. The editors and authors comprise virtually all the top scientists in the field, including the pioneers of protein degradation research and the 2004 Nobel laureate in chemistry.Each volume highlights a different aspect of the field, namely ubiquitin and the chemistry of life, as well as the cell biology and pathology of the ubiquitin-proteasome system, with the individual volumes featuring their own separate indices. Together, all four volumes provide the most comprehensive reference on protein degradation available.

Sklep: Albertus.pl

746,66 zł

Protein-Ligand Interactions Springer-Verlag New York Inc.

Książki / Literatura obcojęzyczna

This third edition provides new and updated chapters detailing a complete introduction to common and emerging procedures for characterizing the interactions of individual proteins with their natural ligands, drugs or other binding partners. Chapters detail natural substrates, potential drug leads, quantitative understanding of the mechanism of interaction, and different techniques. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Protein Ligand Interactions: Methods and Applications, Third Edition serves as an ideal guide for researchers new to the field of biophysical characterization of protein interactions.

Sklep: Libristo.pl

602,78 zł

Cystic Fibrosis Methods and Protocols Humana Press Inc.

Książki / Literatura obcojęzyczna

Since the cloning of the cystic fibrosis transmembrane conductance re- lator (CFTR) nearly a decade ago, cystic fibrosis (CF) research has witnessed a dramatic expansion into new scientific areas. Basic researchers, clinicians, and patients increasingly rely on fundamental techniques of genetics, molecular biology, electrophysiology, biochemistry, cell biology, microbiology, and immunology to understand the molecular basis of this complex disease. Research into the pathophysiology of CF has established numerous paradigms of ion channel dysfunction that extend from inflammation and infection in the airways of patients to basic mechanisms of protein processing and regulation in intracellular components. With these rapid advances has come an increasing need for research scientists to understand and utilize a growing array of basic laboratory tools. This volume of Methods in Molecular Medicine, Cystic Fibrosis Methods and Protocols satisfies that need by providing detailed protocols for the laboratory techniques used throughout CF research. From electrophysiology and cell biology, to animal models and gene therapy, the comprehensive set of methods covered here provide step-by-step instructions needed for investigators to incorporate new approaches into their research programs. Contributions have been chosen to reflect the rich diversity of techniques and to provide a cohesive framework for understanding challenges that are currently at the forefront of CF research. It is hoped that this volume will serve as a valuable reference that will not only foster interdisciplinary investigations into current problems encountered in CF, but also facilitate the translation of new scientific discoveries into clinical solutions.

Sklep: Libristo.pl

549,80 zł

Protein Tyrosine Kinases Humana Press

Zdrowie, medycyna

Leading researchers, from the Novartis group that pioneered Gleevec/Glivec

Sklep: Albertus.pl

574,36 zł

Oxidative Stress: Diagnostic Methods and Applications in Medical Science Springer Verlag, Singapore

Książki / Literatura obcojęzyczna

This book discusses the importance of oxidative stress, related biomarkers, and its diagnostic methods including bio-analytical and advanced detection systems.Oxidative stress is associated with diminished capacity of a biological system to overcome the overproduction of reactive oxygen species. Since oxidative stress has been suggested as a causative factor in many diseases, its prevention is vital, and there is an urgent need for oxidative stress monitoring using in vitro and in vivo models. Interdisciplinary approaches have lead to the development of various oxidative stress monitoring models for real-world clinical and biomedical applications. The development of such methods requires a broad understanding of biology, chemistry, molecular biology, immunology and microbiology. As such, the book is a valuable resource for students, researchers and clinicians interested in the fundamental as well as applied aspects of oxidative stress associated diseases.

Sklep: Libristo.pl

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