239,99 zł

Theoretical & Experimental Investigation Of Protein - Drug Interactions

Książki Obcojęzyczne>Angielskie>Mathematics & science>Biology, life sciences>Biochemistry

0x002e43d600000000

Sklep: Gigant.pl

760,35 zł

Protein-Ligand Interactions Springer-Verlag New York Inc.

Książki / Literatura obcojęzyczna

This third edition provides new and updated chapters detailing a complete introduction to common and emerging procedures for characterizing the interactions of individual proteins with their natural ligands, drugs or other binding partners. Chapters detail natural substrates, potential drug leads, quantitative understanding of the mechanism of interaction, and different techniques. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Protein Ligand Interactions: Methods and Applications, Third Edition serves as an ideal guide for researchers new to the field of biophysical characterization of protein interactions.

Sklep: Libristo.pl

549,80 zł

Protein Tyrosine Kinases Humana Press

Zdrowie, medycyna

Leading researchers, from the Novartis group that pioneered Gleevec/Glivec

Sklep: Albertus.pl

446,26 zł

Advances in Protein Chemistry and Structural Biolog v79 Academic Press

Medycyna > English Division

Structural genomics is the systematic determination of 3-dimensional structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large scale cloning, expression and purification. One main advantage of this approach is economy of scale. This title examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy. It looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission.

Sklep: Ksiazki-medyczne.eu

482,39 zł

Advances in Protein Chemistry and Structural Biology: Vol. 80 Academic Press

Medycyna > English Division

Structural genomics is the systematic determination of 3-dimensional structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large scale cloning, expression and purification. One main advantage of this approach is economy of scale. This title examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy. It looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission.

Sklep: Ksiazki-medyczne.eu

710,89 zł

Drug Discovery in Pancreatic Cancer Springer Verlag

Medycyna > English Division

Pancreatic cancer is the fourth leading cause of cancer death in the United States. Every year, about 33,700 people in the United States will be diagnosed with pancreatic cancer and over 32,000 patients will die from the disease. The median survival of patients with advanced pancreatic cancer is about 6-months. This dismal picture of pancreatic cancer is mainly due to the lack of early diagnosis and effective treatment for patients with advanced disease. To increase the survival rate of pancreatic cancer patients, better tumor markers for diagnosis and new molecular targets for drug development are desperately needed. A lot of effort has been made in searching for pancreatic cancer-causing genes or genes associated with progression of malignant behavior in pancreatic cancer. As a result, alterations in the expression of several cancer-related genes have been identified in pancreatic tumors. The identification and characterization of these cancer-related genes have significantly increased our understanding of pancreatic cancer development, but unfortunately the treatment of pancreatic cancer has not advanced as much in the past 20 years. Over the past decade, tremendous advances have been made in the field of cancer drug discovery, particularly, in the area of molecular and genetic models and technologies. Many of those advanced models and technologies have been applied to the drug discovery processes for pancreatic cancer. In this book, a team of experts will describe the latest development in the application of these models and technologies in pancreatic cancer. The authors include basic researchers as well as clinicians who work in the front-line of the war against pancreatic cancer and have the first-hand experience on these cutting-edge tools and techniques. The book can be divided into two general areas: model systems and genomics and proteomics tools. In recent years there have been a lot of advances in the model systems for pancreatic cancer, including the further characterization of normal and cancerous pancreatic cell lines, the establishment of transgenic mouse models that recapitulate the initiation and progression of human pancreatic cancer, the development of a new xenograft model system for the evaluation of novel agents, and the establishment of a zebrafish pancreatic cancer model. The first four chapters of the book will be devoted to these models. The advances in genomics and proteomics research have made a major impact in cancer drug discovery. A number of these -omics-based tools and techniques have been applied in the pancreatic cancer drug discovery. Chapters 5-9 of the book will discuss techniques for genome-wide examination of gene expression, copy number, methylation, function and regulation. Chapters 10-11 will discuss in situ techniques for studying chromosomal and gene copy number abnormalities as well protein expression changes in cancer samples. Chapters 12-14 will focus on techniques for global examination of protein expression levels in biospecimens obtained from pancreatic cancer patients. Cancer drug discovery has become more and more target-centric.

Sklep: Ksiazki-medyczne.eu

1154,50 zł

Practical Guide to Rational Drug Design Elsevier Science & Technology

Książki / Literatura obcojęzyczna

This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitorsâ

Sklep: Libristo.pl

816,02 zł

Computer-Aided Drug Design Springer Verlag, Singapore

Książki / Literatura obcojęzyczna

This book provides up-to-date information on bioinformatics tools for the discovery and development of new drug molecules. It discusses a range of computational applications, including three-dimensional modeling of protein structures, protein-ligand docking, and molecular dynamics simulation of protein-ligand complexes for identifying desirable drug candidates. It also explores computational approaches for identifying potential drug targets and for pharmacophore modeling.

Sklep: Libristo.pl

732,61 zł

Prokaryotic Systems Biology Springer International Publishing AG

Książki / Literatura obcojęzyczna

This book focuses on innovative experimental and computational approaches for charting interaction networks in bacterial species. The first part of the volume consists of nine chapters, focusing on biochemical and genetics and genomics approaches including yeast two hybrid, metagenomics, affinity purification in combination with mass spectrometry, chromatin-immunoprecipitation coupled with sequencing, large-scale synthetic genetic screens, and quantitative-based mass spectrometry strategies for mapping the bacterial physical, functional, substrate, and regulatory interaction networks needed for interpreting biological networks, inferring gene function, enzyme discovery, and identifying new drug targets.§§The second part comprises five chapters, covering the network of participants for protein folding and complex enzyme maturation. It also covers the structural approaches required to understand bacterial intramembrane proteolysis and the structure and function of bacterial proteins involved in surface polysaccharides, outer membrane, and envelope assembly.§§This volume concludes with a focus on computational and comparative genomics approaches, especially network-based methods for predicting physical or functional interactions, and integrative analytical approaches for generating more reliable information on bacterial gene function. This book provides foundational knowledge in the understanding of prokaryotic systems biology by illuminating how bacterial genes function within the framework of global cellular processes. The book will enable the microbiology community to create substantive resources for addressing many pending unanswered questions, and facilitate the development of new technologies that can be applied to other bacterial species lacking experimental data.§

Sklep: Libristo.pl

571,11 zł

Biophysics Princeton University Press

Książki / Literatura obcojęzyczna

Interactions between the fields of physics and biology reach back over a century, and some of the most significant developments in biology - from the discovery of DNA's structure to imaging of the human brain - have involved collaboration across this disciplinary boundary. For a new generation of physicists, the phenomena of life pose exciting challenges to physics itself, and biophysics has emerged as an important subfield of this discipline. Here, William Bialek provides the first graduate-level introduction to biophysics aimed at physics students. Bialek begins by exploring how photon counting in vision offers important lessons about the opportunities for quantitative, physics-style experiments on diverse biological phenomena. He draws from these lessons three general physical principles - the importance of noise, the need to understand the extraordinary performance of living systems without appealing to finely tuned parameters, and the critical role of the representation and flow of information in the business of life.Bialek then applies these principles to a broad range of phenomena, including the control of gene expression, perception and memory, protein folding, the mechanics of the inner ear, the dynamics of biochemical reactions, and pattern formation in developing embryos. Featuring numerous problems and exercises throughout, "Biophysics" emphasizes the unifying power of abstract physical principles to motivate new and novel experiments on biological systems. It covers a range of biological phenomena from the physicist's perspective. It features 200 problems. It is draws on statistical mechanics, quantum mechanics, and related mathematical concepts. It includes an annotated bibliography and detailed appendixes. It is an instructor's manual (available only to teachers).

Sklep: Libristo.pl

3709,10 zł

Handbook of Nanostructured Biomaterials 2 vols American Scientific Publishers

Inne 1

Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology brings together under a single cover all aspects of the nanostructured biomaterials including all types of nanoscale biomaterials, biocompatible surfaces, functional bioengineered materials, polypeptides, bioceramics, biopolymers, organic-inorganic hybrid biomaterials, nanocomposites, biological macromolecules such as proteins, peptides, nucleic acids, DNA-based self-assemblies, biomolecules, cells, and glycans, biochips, biocompatibility aspects of materials, interactions between biomaterials, cells, tissue and organs, cellular matrix interaction, drug delivery, biomaterials for orthopedic and cardiovascular applications, applications in drug and protein delivery, BioMEMS, dentistry, bone, bioanalysis, biosensors, biomedical implantation, biomechanics, bioinstrumentation, nanoscale physiology and pathology, nanoscale proteomics, instrumentation techniques for nanobioscience, nanoscale cellular and tissue engineering, etc. Broadly speaking, all important aspects dealing with the chemistry, physics, biology and engineering of nanostructured biomaterials and their applications in nanobiotechnology are covered. The two-volumes contain over 30 state-of-the-art review chapters written by over 70 internationally renowned experts from 10 countries. The handbook has been divided into two thematic volumes.

Sklep: Albertus.pl

1667,43 zł

Circular Dichroism - Principles and Applications 2e John Wiley & Sons Inc

Książki / Literatura obcojęzyczna

Multidisciplinary coverage of circular dichroism's principles, applications, and latest advances The four years since the publication of the first edition of Circular Dichroism: Principles and Applications have seen a rapid expansion of the field, including new applications, improved understanding of principles, and a growing interest in circular dichroism (CD) among researchers from a wide variety of disciplines. The Second Edition keeps pace with this phenomenal growth with up-to-date contributions from dozens of the world's leading researchers and practitioners in chirality, chemistry, biochemistry, and analytical chemistry, as well as vibrational and luminescence spectroscopy. With nine entirely new chapters and substantial updates of existing material, Circular Dichroism, Second Edition provides important insight into the immense potential of CD and bridges the gap between theory and practice. The book begins with coverage of historical developments and moves quickly to fascinating reports on recent advances and emerging new fields in CD.New and updated coverage includes: VOA theory Solid-state CD applications Fast time-resolved CD measurements A model illustrating how polymers amplify chirality Induced CD of polymers CD of nucleic acids: nonclassical conformations and modified oligonucleotides DNA-drug and DNA-protein interactions Applications of CD to important pharmaceutical compounds Featuring an increased emphasis on biological molecules and extensive applications to organic stereochemistry and biopolymers, Circular Dichroism: Principles and Applications, Second Edition will prove a valuable and frequently consulted reference for organic chemists, biochemists, and medicinal and pharmaceutical chemists.

Sklep: Libristo.pl

715,02 zł

Nutrition in Kidney Disease Springer Nature Switzerland AG

Książki / Literatura obcojęzyczna

This third edition of this text is organized into seven sections that address the educational needs of dietitians around the world who seek current information about nutritional management of chronic kidney disease (CKD). Part I addresses the differences in the epidemiology of CKD and renal replacement therapy worldwide, such as environmental, ethnic, cultural, political and macroeconomic factors. Part II includes a thorough review of the components of the nutrition assessment, which includes information about psychosocial issues affecting nutritional status in kidney disease and drug-nutrient interactions, and parts III and IV review preventative strategies for common disorders associated with CKD such as hypertension, type 2 diabetes, obesity and cardiovascular disease are provided, and current evidence-based treatment recommendations for the nutrition management of non-dialyzed, dialyzed and transplanted adults are addressed. Part V presents the nutritional concerns of CKD populations with special needs (i.e., pregnancy, infancy, childhood, adolescence and the elderly). The nutrition management of other disorders associated with kidney disease are covered in Part VI; these include protein-energy wasting and the inflammatory response, bone and mineral disorders, nephrotic syndrome, nephrolithiasis, and acute kidney injury. Lastly, Part VII is devoted to cutting-edge research on topics of concern in nutrition in kidney disease such as the gut microbiome including pre- and probiotics, appetite regulation, advanced glycation end products, physical activity and structured exercise, and dietary patterns including plant-based diets. When appropriate, the new clinical practice guidelines in nutrition for individuals with CKD are integrated into the chapters. The third edition of Nutrition in Kidney Disease will be a highly informative resource for nephrologists, nutrition scientists, nutritionists, and researchers and students whose research, practice, and education includes nutrition and kidney disease.

Sklep: Libristo.pl

479,86 zł

Targeting Oral Cancer Springer International Publishing AG

Książki / Literatura obcojęzyczna

This book provides research-oriented care providers with up-to-date information on the oral cancer patient population, the ways in which we are treating them, and the scientific approaches being pursued in order to improve survival and reduce treatment-related morbidity. The text is organized into three sections covering epidemiology and management, cancer development and biomarkers, and breaking developments and novel approaches for drug discovery. The first section includes discussion of the emerging role of HPV in oral cancer and explains the surgical, chemotherapy and radiation approaches to treatment. Aspects such as molecular progression, the role of cancer stem cells in tumor development, and the value of various biomarkers are then examined. The final section is devoted to the latest advances and covers, among other topics, current clinical trials, emerging drug targets, and targeting of the unfolded protein response and of mediators of coagulation.

Sklep: Libristo.pl

728,20 zł

Oncogenomics Handbook Humana Press

Zdrowie, medycyna

An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.

Sklep: Albertus.pl

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