Practical Guide to Rational Drug Design Elsevier Science & Technology

Książki / Literatura obcojęzyczna

This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitorsâ

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A Practical Guide To Rational Drug Design

Książki Obcojęzyczne>Angielskie>Mathematics & science>Science: general issues

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Rational Drug Design Of Substituted Analogues Angiotensin II Receptor

Książki Obcojęzyczne>Angielskie>Medicine>Other branches of medicine>Pharmacology

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Contribution of Rational Drug Design for Efficacious Target Interactions

Książki

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Deoxynucleoside Analogs In Cancer Therapy Humana Press

Medycyna > English Division

Emerging as an important new volume in the renowned Cancer Drug Discovery and Development' series, Deoxynucleoside Analogs in Cancer Therapy expertly summarizes the current status of development and application of deoxynucleoside analogs. Authoritative up-to-date reviews are presented by scientists well known in their specific areas and all contributions include valuable sound advice on structure and topics. Organized into several sections, the first part covers general aspects of drug uptake and metabolism and explains how novel technology has enabled a rapid expansion of this field. The second part is concerned with a number of specific drugs including cytarabine, gemcitabine, troxacitabine, clofarabine and ara-G. The final section covers pharmacokinetics, prodrugs, and specific applications such as radiosensitization, gene therapy, and the use of deoxynucleoside analogs as tracers. Throughout Deoxynucleoside Analogs in Cancer Therapy, the focus is on novel aspects of deoxynucleoside analogs in the clinical context, as well as on unexpected targets of these compounds, such as their specific activity against cell cycle-dependent kinases or oncogenes. The wealth of information presented here can be used to design rational combinations aimed at inhibiting various cellular signaling pathways, or combining inhibition of various targets. Deoxynucleoside Analogs in Cancer Therapy has been designed specifically to facilitate such an interaction between various fields. "...a top-notch overview of the current knowledge in the area of deoxynucleoside analog development and application in the treatment of cancer." -Weighted Numerical Score: 92 - 4 Stars!-Doody's Health Science Book Review Journal "...an excellent book that is suitable for researchers or clinicians with an interest in deoxynucleoside analgos and/or cancer chemotherapy." -Weighted Numerical Score: 92 - 4 Stars!-Doody's Health Science Book Review Journal

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Deoxynucleoside Analogs In Cancer Therapy Humana Press

Inne 1

Emerging as an important new volume in the renowned Cancer Drug Discovery and Development

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Epigenetic Cancer Therapy Elsevier Science & Technology

Książki / Literatura obcojęzyczna

Epigenetic Cancer Therapy, Second Edition provides a comprehensive discussion of healthy and aberrant epigenetic biology, and the potential new discoveries hold to improve our understanding of cancer epigenetics and therapeutics. The book encompasses both large-scale intergovernmental initiatives, as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Since the publication of the first edition of this book, the field of epigenetics has undergone significant change. New epigenetic therapies have been designed and approved for clinical use. Our knowledge of the plasticity of the epigenome in cancer and disease has expanded dramatically. Increasing evidence links pollution to epigenetic changes in cancer development. This second edition has been fully updated to address these changes, along with promising therapeutic programs such as CRISPR/Cas9 mediated approaches, CAR-T based therapies, epigenetic priming, histone modifications, and similar, transformative advances across synthetic biology and cellular engineering. Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs Fully updated to address new topics, including the epitranscriptome, oncohistones, single cell analysis, epigenetic priming, CRISPR therapy, CAR-T therapy, and epigenetics and pollution Features chapter contributions from leading experts in the field

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