Research in Computational Molecular Biology Springer Verlag

Medycyna > English Division

This book constitutes the refereed proceedings of the 14th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2010, held in Lisbon, Portugal, in April 2010. The 36 revised full papers were carefully reviewed and selected from 176 submissions. The papers cover all areas of computational molecular biology such as molecular sequence analysis; recognition of genes and regulatory elements; molecular evolution; gene expression; biological networks; sequencing and genotyping technologies; genomics; population genetics; systems biology; imaging; computational proteomics; and molecular structural biology.

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Research In Computational Molecular Biology

Książki Obcojęzyczne>Angielskie>Mathematics & science>Science: general issues>Maths for scientistsKsiążki Obcojęzyczne>Angielskie>Co...

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Research in Computational Molecular Biology: 21st Annual International Conference, Recomb 2017, Hong Kong, China, May 3-7, 2017, Proceedings

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Fundamentals of Bioinformatics and Computational Biology Springer International Publishing AG

Książki / Literatura obcojęzyczna

This book offers comprehensive coverage of all the core topics of bioinformatics, and includes practical examples completed using the MATLAB bioinformatics toolbox . It is primarily intended as a textbook for engineering and computer science students attending advanced undergraduate and graduate courses in bioinformatics and computational biology. The book develops bioinformatics concepts from the ground up, starting with an introductory chapter on molecular biology and genetics. This chapter will enable physical science students to fully understand and appreciate the ultimate goals of applying the principles of information technology to challenges in biological data management, sequence analysis, and systems biology. The first part of the book also includes a survey of existing biological databases, tools that have become essential in today s biotechnology research. The second part of the book covers methodologies for retrieving biological information, including fundamental algorithms for sequence comparison, scoring, and determining evolutionary distance. The main focus of the third part is on modeling biological sequences and patterns as Markov chains. It presents key principles for analyzing and searching for sequences of significant motifs and biomarkers. The last part of the book, dedicated to systems biology, covers phylogenetic analysis and evolutionary tree computations, as well as gene expression analysis with microarrays. In brief, the book offers the ideal hands-on reference guide to the field of bioinformatics and computational biology.

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Principles of Neural Science, Fifth Edition McGraw-Hill Education - Europe

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Now updated: the definitive neuroscience resource from Eric R. Kandel, MD (winner of the Nobel Prize in 2000); James H. Schwartz, MD, PhD; Thomas M. Jessell, PhD; Steven A. Siegelbaum, PhD; and A. J. Hudspeth, PhD § 900 full-color illustrations§Deciphering the link between the human brain and behavior has always been one of the most intriguing and often challenging aspects of scientific endeavor. The sequencing of the human genome, and advances in molecular biology, have illuminated the pathogenesis of many neurological diseases and have propelled our knowledge of how the brain controls behavior.§To grasp the wider implications of these developments and gain a fundamental understanding of this dynamic, fast-moving field, Principles of Neuroscience stands alone as the most authoritative and indispensible resource of its kind.§In this classic text, prominent researchers in the field expertly survey the entire spectrum of neural science, giving an up-to-date, unparalleled view of the discipline for anyone who studies brain and mind. Here, in one remarkable volume, is the current state of neural science knowledge ranging from molecules and cells, to anatomic structures and systems, to the senses and cognitive functions all supported by more than 900 precise, full-color illustrations. In addition to clarifying complex topics, the book also benefits from a cohesive organization, beginning with an insightful overview of the interrelationships between the brain, nervous system, genes, and behavior. Principles of Neural Science then proceeds with an in-depth examination of the molecular and cellular biology of nerve cells, synaptic transmission, and the neural basis of cognition. The remaining sections illuminate how cells, molecules, and systems give us sight, hearing, touch, movement, thought, learning, memories, and emotions.§The new fifth edition of Principles of Neural Science is thoroughly updated to reflect the tremendous amount of research, and the very latest clinical perspectives, that have significantly transformed the field within the last decade.§Ultimately, Principles of Neural Science affirms that all behavior is an expression of neural activity, and that the future of clinical neurology and psychiatry hinges on the progress of neural science. Far exceeding the scope and scholarship of similar texts, this unmatched guide offers a commanding, scientifically rigorous perspective on the molecular mechanisms of neural function and disease one that you ll continually rely on to advance your comprehension of brain, mind, and behavior.§FEATURES§The cornerstone reference in the field of neuroscience that explains how the nerves, brain, and mind function§Clear emphasis on how behavior can be examined through the electrical activity of both individual neurons and systems of nerve cells§Current focus on molecular biology as a tool for probing the pathogenesis of many neurological diseases, including muscular dystrophy, Huntington disease, and certain forms of Alzheimer s disease§More than 900 engaging full-color illustrations including line drawings, radiographs, micrographs, and medical photographs clarify often-complex neuroscience concepts§Outstanding section on the development and emergence of behavior, including important coverage of brain damage repair, the sexual differentiation of the nervous system, and the aging brain§NEW! More detailed discussions of cognitive and behavioral functions, and an expanded review of cognitive processes§NEW! A focus on the increasing importance of computational neural science, which enhances our ability to record the brain s electrical activity and study cognitive processes more directly§NEW! Chapter-opening Key Concepts provide a convenient, study-enhancing introduction to the material covered in each chapter§Selected Readings and full reference citations at the close of each chapter facilitate further study and research§Helpful appendices highlight basic circuit theory; the

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Biocomputing 2004 Proceedings of the Pacific Symposium World Scientific Publishing Co Ltd

Medycyna > English Division

The Pacific Symposium on Biocomputing (PSB 2004) is an international, multidisciplinary conference for the presentation and discussion of current research on the theory and application of computational methods in problems of biological significance. The rigorously peer-reviewed papers and presentations are collected in this archival proceedings volume. PSB is a forum for the presentation of work on databases, algorithms, interfaces, visualization, modeling and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology. PSB 2004 brings together top researchers from the US, the Asia-Pacific region and the rest of the world to exchange research findings and address open issues in all aspects of computational biology.

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Biocomputing 2004 Proceedings of the Pacific Symposium World Scientific Publishing Co Ltd

Inne 1

The Pacific Symposium on Biocomputing (PSB 2004) is an international, multidisciplinary conference for the presentation and discussion of current research on the theory and application of computational methods in problems of biological significance. The rigorously peer-reviewed papers and presentations are collected in this archival proceedings volume. PSB is a forum for the presentation of work on databases, algorithms, interfaces, visualization, modeling and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology. PSB 2004 brings together top researchers from the US, the Asia-Pacific region and the rest of the world to exchange research findings and address open issues in all aspects of computational biology.

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Transcriptomics and Gene Regulation Springer

Książki / Literatura obcojęzyczna

This volume focuses on modern computational and statistical tools for translational gene expression and regulation research to improve prognosis, diagnostics, prediction of severity, and therapies for human diseases. It introduces some of state of the art technologies as well as computational and statistical tools for translational bioinformatics in the areas of gene transcription and regulation, including the tools for next generation sequencing analyses, alternative spicing, the modeling of signaling pathways, network analyses in predicting disease genes, protein and gene expression data integration, and the influence of genetic variation such as single nucleotide polymorphisms on gene expression in complex human diseases etc. The book is useful for researchers and students in the field of molecular biology, clinical biology and bioinformatics, and physicians etc. Dr. Wu is assistant professor in the Vivian L. Smith Department of Neurosurgery, University of Texas Health Science Centre, Houston, USA.

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Algorithms on Trees and Graphs Springer Nature Switzerland AG

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Graph algorithms is a well-established subject in mathematics and computer science. Beyond classical application fields, such as approximation, combinatorial optimization, graphics, and operations research, graph algorithms have recently attracted increased attention from computational molecular biology and computational chemistry. Centered around the fundamental issue of graph isomorphism, this text goes beyond classical graph problems of shortest paths, spanning trees, flows in networks, and matchings in bipartite graphs. Advanced algorithmic results and techniques of practical relevance are presented in a coherent and consolidated way. This book introduces graph algorithms on an intuitive basis followed by a detailed exposition in a literate programming style, with correctness proofs as well as worst-case analyses. Furthermore, full C++ implementations of all algorithms presented are given using the LEDA library of efficient data structures and algorithms.

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Nanopore Technology Springer-Verlag New York Inc.

Książki / Literatura obcojęzyczna

This detailed collection explores techniques involved in the main strategies of nanopore sensing, such as translocation, analyte trapping, and interactions with external binding sites. Opening with a section on nanopore design and nanopore production, the book continues with parts devoted to various biological nanopores, nanopore engineering, and their uses in single molecule sensing, computational methods to study intrinsic nanopore behavior, characterizing the specific translocation activity of a vesicle particle through a nanopore, as well as the use of the technique droplet interface bilayer (DIB) in nanopore and membrane biophysical studies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Nanopore Technology: Methods and Protocols, with its focus on nanopore technology and biomolecule characterization, will hold the interest of the biophysicists, biochemists, bioengineers, and molecular biologists who are working toward further understanding this key field of research.

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Modern Genome Annotation Springer Verlag GmbH

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An accurate description of current scientific developments in the field of bioinformatics and computational implementation is presented by research of the BioSapiens Network of Excellence. Bioinformatics is essential for annotating the structure and function of genes, proteins and the analysis of complete genomes and to molecular biology and biochemistry. §Included is an overview of bioinformatics, the full spectrum of genome annotation approaches including; genome analysis and gene prediction, gene regulation analysis and expression, genome variation and QTL analysis, large scale protein annotation of function and structure, annotation and prediction of protein interactions, and the organization and annotation of molecular networks and biochemical pathways. Also covered is a technical framework to organize and represent genome data using the DAS technology and work in the annotation of two large genomic sets: HIV/HCV viral genomes and splicing alternatives potentially encoded in 1% of the human genome.

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Practical Guide to Rational Drug Design Elsevier Science & Technology

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This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitorsâ

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Many Faces of RNA Academic Press

Medycyna > English Division

The Many Faces of RNA is the subject for the eighth SmithKline Beecham Pharmaceuticals Research Symposia. It highlights a rapidly developing area of scientific investigation. The style and format are deliberately designed to promote in-depth presentations and discussions and to facilitate the forging of collaborations between academic and industrial partners. This symposium focuses on several of the many fundamental, advancing strategies for exploring RNA and its functions. It emphasizes the interplay between biology, chemistry, genomics, and molecular biology which is leading to exciting new insights and avenues of investigation. The book explores RNA as a therapeutic target, RNA as a tool, RNA and its interactions, along with chemical, computational, and structural investigations.

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Cytochrome P450 Springer, Berlin

Książki / Literatura obcojęzyczna

In this third edition of Cytochrome P450: Structure, Mechanism, and Biochemistry, Dr. Paul Ortiz de Montellano has brought together a group of new authors as well as authors from previous editions to produce a timely volume that will be of considerable interest to a broad array of P450 researchers.§The explosion of discovery of CYP (cytochrome P450) genes through genome analysis more than 3500 to date provides the more than 10,000 scientists around the world who study these monooxygenases a rich source of interesting and important research problems. Many have remained central elements over the 18 years that span the three editions of this book, including mechanisms of catalysis, oxygen activation and inhibition, gene regulation, and P450 structure. Each new edition updates our knowledge of such central issues in the study of P450s, emphasizing the timeliness of this newest volume.§In this newest edition, we find that the newest discussion of P450 structure includes information of bacterial (soluble) P450s interwoven with that of eukaryotic (membrane bound) of this superfamily, highlighting the newest developments in this area. The complete battery of human P450s is now known and summarized in the new edition. In addition, general overviews of plant P450s and those from microbes contained within this newest edition provide a broader view of P450 diversity than seen in earlier editions. Each of these three editions should be on bookshelves of laboratories studying P450s. The third edition of Cytochrome P450: Structure, Mechanism, and Biochemistry provides an opportunity to judge progress in many key areas of P450 research while at the same time learn of new directions in the field. It is an excellent and most useful volume.§Dr. Michael R. Waterman, Ph.D., Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN§The third edition of Cytochrome P450: Structure, Mechanism, and Biochemistry provides an exceptionally fine summary of our present knowledge of the remarkable hemoprotein often called "nature s most versatile biological catalyst." Edited by Paul Ortiz de Montellano, with chapters by many of the world s experts in this rapidly developing field, this edition includes major advances in the past decade such as the crystal structure of membrane-bound forms of the enzyme and evidence for multiple species of activated oxygen, based in part on the use of radical clocks and computational approaches. The sequences of several thousand P450s are now known, and recent progress in understanding the properties and functions of those in the microbial and plant worlds, as well as the better known mammalian isozymes, is now included. §The versatility of cytochrome P450 includes the ability to metabolize innumerable substrates of both physiological and xenobiotic importance, and to be markedly altered in activity by a wide variety of inducers and inhibitors. Accordingly, this new edition will be invaluable to scientists in fields as diverse as biochemistry, chemistry, biophysics, molecular biology, pharmacology, and toxicology.§M. J. Coon, Victor C. Vaughan Distinguished University Professor of Biological Chemistry, Emeritus, The University of Michigan Medical School, Ann Arbor, MI

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Many Faces of RNA Academic Press

Zdrowie, medycyna

The Many Faces of RNA is the subject for the eighth SmithKline Beecham Pharmaceuticals Research Symposia. It highlights a rapidly developing area of scientific investigation. The style and format are deliberately designed to promote in-depth presentations and discussions and to facilitate the forging of collaborations between academic and industrial partners.This symposium focuses on several of the many fundamental, advancing strategies for exploring RNA and its functions. It emphasizes the interplay between biology, chemistry, genomics, and molecular biology which is leading to exciting new insights and avenues of investigation. The book explores RNA as a therapeutic target, RNA as a tool, RNA and its interactions, along with chemical, computational, and structural investigations.

Sklep: Albertus.pl