563,70 zł

Imaging in CNS Drug Discovery and Development Springer Verlag

Zdrowie, medycyna

Imaging is a key area of translational research that provides a unique bridge from the laboratory to the clinic as the same techniques and technologies can applied across the various phases of drug development. Neuroimaging is now central to research and drug development in the neurosciences since it can be used to detect the pharmacological and physiological consequences of drug action within the living brain. Today neuroimaging is used primarily as a biomarker to help optimize our decision-making processes. Neuroimaging tools and technologies can be used to select drug candidates, confirm they engage their targets, link occupancy to biology and then, in a translational fashion, be used to help design the best clinical studies that truly test therapeutic hypotheses. Neuroimaging today is all about the need to identify the best molecules, doses and hypotheses to advance into later stage long term extensive clinical trials that can often be confounded by high placebo response rates. Better decision making in early development allows resources to be focused on the drug candidates and therapeutic hypotheses that have the highest probability of success so that we can bring medical advances to patients as quickly as possible. Imaging in CNS Drug Discovery and Development was written by a group of preeminent international experts in the field of imaging.Topics covered include: * The role of imaging in drug development * Imaging approaches including structural, functional, molecular and chemical imaging * Imaging drug action including neuroreceptor mapping to examine drug occupancy characteristics, the involvement of specific neurotransmitter systems in CNS diseases and mechanisms of action * Functional mapping to provide pharmacodynamic evidence of central activity, "CNS fingerprinting" of the neuroanatomy of drug effects and disease drug interactions * Imaging disease states in preclinical and clinical domains

Sklep: Albertus.pl

1119,32 zł

Pharmacogenomics in Drug Discovery and Development Springer, Berlin

Książki / Literatura obcojęzyczna

This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care. Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.

Sklep: Libristo.pl

732,61 zł

Prokaryotic Systems Biology Springer International Publishing AG

Książki / Literatura obcojęzyczna

This book focuses on innovative experimental and computational approaches for charting interaction networks in bacterial species. The first part of the volume consists of nine chapters, focusing on biochemical and genetics and genomics approaches including yeast two hybrid, metagenomics, affinity purification in combination with mass spectrometry, chromatin-immunoprecipitation coupled with sequencing, large-scale synthetic genetic screens, and quantitative-based mass spectrometry strategies for mapping the bacterial physical, functional, substrate, and regulatory interaction networks needed for interpreting biological networks, inferring gene function, enzyme discovery, and identifying new drug targets.§§The second part comprises five chapters, covering the network of participants for protein folding and complex enzyme maturation. It also covers the structural approaches required to understand bacterial intramembrane proteolysis and the structure and function of bacterial proteins involved in surface polysaccharides, outer membrane, and envelope assembly.§§This volume concludes with a focus on computational and comparative genomics approaches, especially network-based methods for predicting physical or functional interactions, and integrative analytical approaches for generating more reliable information on bacterial gene function. This book provides foundational knowledge in the understanding of prokaryotic systems biology by illuminating how bacterial genes function within the framework of global cellular processes. The book will enable the microbiology community to create substantive resources for addressing many pending unanswered questions, and facilitate the development of new technologies that can be applied to other bacterial species lacking experimental data.§

Sklep: Libristo.pl

710,89 zł

Drug Discovery in Pancreatic Cancer Springer Verlag

Medycyna > English Division

Pancreatic cancer is the fourth leading cause of cancer death in the United States. Every year, about 33,700 people in the United States will be diagnosed with pancreatic cancer and over 32,000 patients will die from the disease. The median survival of patients with advanced pancreatic cancer is about 6-months. This dismal picture of pancreatic cancer is mainly due to the lack of early diagnosis and effective treatment for patients with advanced disease. To increase the survival rate of pancreatic cancer patients, better tumor markers for diagnosis and new molecular targets for drug development are desperately needed. A lot of effort has been made in searching for pancreatic cancer-causing genes or genes associated with progression of malignant behavior in pancreatic cancer. As a result, alterations in the expression of several cancer-related genes have been identified in pancreatic tumors. The identification and characterization of these cancer-related genes have significantly increased our understanding of pancreatic cancer development, but unfortunately the treatment of pancreatic cancer has not advanced as much in the past 20 years. Over the past decade, tremendous advances have been made in the field of cancer drug discovery, particularly, in the area of molecular and genetic models and technologies. Many of those advanced models and technologies have been applied to the drug discovery processes for pancreatic cancer. In this book, a team of experts will describe the latest development in the application of these models and technologies in pancreatic cancer. The authors include basic researchers as well as clinicians who work in the front-line of the war against pancreatic cancer and have the first-hand experience on these cutting-edge tools and techniques. The book can be divided into two general areas: model systems and genomics and proteomics tools. In recent years there have been a lot of advances in the model systems for pancreatic cancer, including the further characterization of normal and cancerous pancreatic cell lines, the establishment of transgenic mouse models that recapitulate the initiation and progression of human pancreatic cancer, the development of a new xenograft model system for the evaluation of novel agents, and the establishment of a zebrafish pancreatic cancer model. The first four chapters of the book will be devoted to these models. The advances in genomics and proteomics research have made a major impact in cancer drug discovery. A number of these -omics-based tools and techniques have been applied in the pancreatic cancer drug discovery. Chapters 5-9 of the book will discuss techniques for genome-wide examination of gene expression, copy number, methylation, function and regulation. Chapters 10-11 will discuss in situ techniques for studying chromosomal and gene copy number abnormalities as well protein expression changes in cancer samples. Chapters 12-14 will focus on techniques for global examination of protein expression levels in biospecimens obtained from pancreatic cancer patients. Cancer drug discovery has become more and more target-centric.

Sklep: Ksiazki-medyczne.eu

448,49 zł

BIOLOGY A GLOBAL APPROACH GLOBAL EDITION NOWA URRY WYDAWCA

Podręczniki, artykuły szkolne > Podręczniki do szkół podst. i średnich

Biology: A Global Approach, Global Edition   Biology: A Global Approach   delivers a trusted, accurate, current, and pedagogically innovative experience that guides students to a true understanding of biology. The author team advances Neil Campbell

Sklep: ksiazkitanie.pl

9557,32 zł

Wiley Encyclopedia of Chemical Biology 4V SET John Wiley & Sons Inc

Książki / Literatura obcojęzyczna

The Wiley Encyclopedia of Chemical Biology is an authoritative new work whose goal is to illuminate the crucial role of chemistry and chemical techniques in the life sciences. The encyclopedia will adopt an inclusive editorial approach, encompassing fundamental and blue-sky science as well as those areas of research that have more immediate medical or commercial applications. The scope and structure of the work will reflect the multidimensional character of chemical biology, focusing in particular on the fundamental science of biological structures and systems, the use of chemical and biological techniques to elucidate that science, and the applications of this knowledge in areas as diverse as drug discovery, sensor technology, and catalysis.Major topics areas covered in the encyclopedia: Chemical Views of Biology Biomolecules within the Cell Chemistry of Biological Processes and Systems Chemical Biology of Cellular Compartments Synthetic Molecules as Tools for Chemical Biology Technologies and Techniques in Chemical Biology Applications of Chemical Biology

Sklep: Libristo.pl

444,54 zł

Drug Screening Methods Anshan Ltd

Medycyna > English Division

Drug discovery and development is a challenging, expensive and time consuming field of research, requiring contributions from chemists, pharmacologists, toxicologists, clinicians, and practitioners. The ultimate goal is to generate a safe and biologically active drug which can stall, or even reverse, the pathological events that cause the disease condition. But in the search for the drug a host of tests and trials must be applied to evaluate the efficiency and safety of the newly developed molecule in the biological system. These trials or "screening methods" are critical. On their basis, the new molecule either becomes accepted for usage, or is discarded forever. Advances in drug research have forced the need for quicker, more automated screening methods, using molecular techniques applied in vitro, in vivo and in clinical systems. Researchers need to know the latest developments outside their own speciality. With this book, Professor Gupta has brought together in one coherent volume the most up to date developments of consolidated screening methods for biological systems. By paying attention to the practical techniques used in academia and the commercial pharmaceutical industry, "Drug Screening Methods" will enjoy a broad readership, serving both the professional community and the student of pharmacology.

Sklep: Ksiazki-medyczne.eu

450,80 zł

Drug Screening Methods Anshan Ltd

Zdrowie, medycyna

Drug discovery and development is a challenging, expensive and time consuming field of research, requiring contributions from chemists, pharmacologists, toxicologists, clinicians, and practitioners. The ultimate goal is to generate a safe and biologically active drug which can stall, or even reverse, the pathological events that cause the disease condition. But in the search for the drug a host of tests and trials must be applied to evaluate the efficiency and safety of the newly developed molecule in the biological system. These trials or "screening methods" are critical. On their basis, the new molecule either becomes accepted for usage, or is discarded forever. Advances in drug research have forced the need for quicker, more automated screening methods, using molecular techniques applied in vitro, in vivo and in clinical systems. Researchers need to know the latest developments outside their own speciality. With this book, Professor Gupta has brought together in one coherent volume the most up to date developments of consolidated screening methods for biological systems. By paying attention to the practical techniques used in academia and the commercial pharmaceutical industry, "Drug Screening Methods" will enjoy a broad readership, serving both the professional community and the student of pharmacology.

Sklep: Albertus.pl

29,70 zł

DISCOVERY - 48 GODZIN Z BEAREM GRYLLSEM (2DVD) (Płyta DVD)

Książki & Multimedia > Filmy Video

Opis - Bear Grylls, ekspert w dziedzinie sztuki przetrwania i niekwestionowana gwiazda Discovery Channel powraca do akcji - tym razem w towarzystwie

Sklep: InBook.pl

11,15 zł

Spalona Żywcem Wyd. Kieszonkowe - Souad

Książki & Multimedia > Książki

Opis - Pierwsze na świecie świadectwo ofiary zbrodni honorowej. Miała siedemnaście lat i zakochała się: zhańbiła rodzinę. Więc rodzina wydała na nią wyrok śmierci... Pokochała go pierwszą miłością. Myślała, że się z nią ożeni. Ale ukochany zniknął, a ona odkryła, że jest w ciąży. A w jej świecie to najcięższa zbrodnia... W zapomnianej przez Boga wiosce w Cisjordanii kobiety są warte mniej niż zwierzęta domowe. Tu mężczyzna jest panem życia i śmierci żony, córki, siostry. Brat może bezkarnie zabić siostrę, matka - córkę, kolejną bezużyteczną dziewczynkę, jaka się urodzi. Tu kobiecie odbiera się godność, a nawet życie zgodnie z odwiecznym obyczajem i uświęconą tradycją. A śmierć jest karą dla dziewczyny, która zhańbi rodzinę. Tak jak Souad. Wyrok wydaje jej ojciec. Szwagier dokonuje egzekucji. Oblewa Souad benzyną i podpala... SOUAD przeżyła - cudem, ale rodzina usiłowała zabić ją nawet w szpitalu. Na zawsze jednak pozostanie straszliwie okaleczona - na ciele i duszy. I wciąż musi się ukrywać; dopóki żyje, jej rodzinę okrywa hańba. Spalona żywcem, opublikowana pod pseudonimem szokująca opowieść o piekle, jakim było jej dzieciństwo i młodość, stała się międzynarodowym bestsellerem. Wydana w 37 w krajach książka przerywa tabu milczenia wobec istniejącej nadal w krajach muzułmańskich barbarzyńskiej tradycji. Nieludzkiego obyczaju, prawa mężczyzn, na mocy którego co najmniej pięć tysięcy kobiet pada co roku ofiarą zbrodni honorowej. Nazwa - Spalona Żywcem Wyd. Kieszonkowe Autor - Souad Oprawa - Miękka Wydawca - Amber Kod ISBN - 9788324159406 Kod EAN - 9788324159406 Wydanie - 1 Rok wydania - 2016 Tłumacz - 31182,maria rostworowska; Format - 110 x 175 x 14 Ilość stron - 224 Podatek VAT - 5% Premiera - 2016-06-23

Sklep: InBook.pl

508,50 zł

Handbook of Medicinal Chemistry ROYAL SOCIETY OF CHEMISTRY

Książki / Literatura obcojęzyczna

Drug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry covers the past, present and future of the entire drug development process. Highlighting the recent successes and failures in drug discovery, the book will help readers to understand the factors governing modern drug discovery from the initial concept through to a marketed medicine. With chapters covering a wide range of topics from drug discovery processes and optimization, development of synthetic routes, pharmaceutical properties and computational biology, the handbook aims to help medicinal chemists to apply their academic understanding to every aspect of drug discovery. Each chapter includes expert advice to not only provide a rigorous understanding of the principles being discussed, but to provide useful hints and tips gained from within the pharmaceutical industry. This expertise, combined with project case studies, highlighting and discussing all areas of successful projects, make this an essential handbook for all those involved in pharmaceutical development.

Sklep: Libristo.pl

728,20 zł

Oncogenomics Handbook Humana Press

Zdrowie, medycyna

An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.

Sklep: Albertus.pl

291,33 zł

General Surgery John Wiley & Sons Inc

Książki / Literatura obcojęzyczna

Drug discovery and development is an expensive multi-disciplinary effort dependent on chemistry, structural biology, molecular and cell biology, pharmacology, physiology, statistics, computer sciences, engineering, medicine, law and business. It is a major challenge to incorporate all these fields into a single course, however it is also an opportunity to provide advanced students with a unifying context in which to apply knowledge from foundation courses. Rather than simply describing the drug discovery process, an essential goal of this text is to introduce the key decisions that are involved, the types of information needed to make these decisions, and the types of experiments used to obtain that information. In my teaching I have found that focusing on core concepts makes the subject accessible to a wider range of students and facilitates the integration of the knowledge into a context that is accessible and meaningful. This approach also serves to reinforce basic skills of research design and interpretation, and of data-driven decision-making skills relevant for a large number of potential learning and career directions. This book is intended to provide students with an understanding of the primary steps in the drug discovery and development process, key information needs associated with the decisions that govern the progression of projects from lab to clinic to market, and major research approaches used to provide information, support decision-making, and identify/prioritize candidate drug targets and candidate molecules. Along with a focus on the decision-making process, the text will emphasize the fundamental principles of science. Textboxes will highlight core concepts, techniques, and historic case examples, including examples from global infectious diseases such as malaria and sleeping sickness. End-of-chapter questions, a glossary and a math appendix will ensure that the text is accessible to upper-level undergraduates and graduate students.

Sklep: Libristo.pl

1169,37 zł

Hepatitis C Caister Academic Press

Książki / Literatura obcojęzyczna

The hepatitis C virus (HCV) is a significant public health problem of international importance. HCV is capable of establishing chronic infections resulting in progressive liver damage and other problems. Current drug therapies are ineffective, highlighting the need for better antiviral drugs. Recent research in HCV genetics and molecular biology have led to significant advances in our understanding of the life cycle of this important pathogen and may ultimately lead to better antiviral strategies. The editors of this book have recruited experts from around the world to produce a timely and well-compiled review of current HCV research, with an emphasis on antiviral drug development. The chapters provide in-depth reviews of the most critical areas of research. Topics include: the HCV life cycle * HCV assays * HCV resources * HCV databases * HCV infection systems * models of hepatitis C infections * overview of the drug pipeline * clinical trial design * clinical virology and drug development * NS3 protease inhibitors * NS3-NS4A complex inhibitors * NS3 helicase inhibitors * NS4B targets and inhibitors * NS5A inhibitors * nucleoside inhibitors * NS5B polymerase inhibitors * glycoprotein-dependent entry * host cell targets and inhibitors * innate immunity for HCV antiviral therapy.

Sklep: Libristo.pl

549,80 zł

Protein Tyrosine Kinases Humana Press

Zdrowie, medycyna

Leading researchers, from the Novartis group that pioneered Gleevec/Glivec

Sklep: Albertus.pl

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