krainaksiazek an introduction to mathematics for computing and it practitioners 20090730
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Molecular Structures and Structural Dynamics of Prion Proteins and Prions Springer Netherlands
Książki / Literatura obcojęzyczna
This monograph is the first easy-to-read-and-understand book on prion proteins' molecular dynamics (MD) simulations and on prions' molecular modelling (MM) constructions. It enables researchers to see what is crucial to the conformational change from normal cellular prion protein (PrP C ) to diseased infectious prions (PrP Sc ), using MD and MM techniques. As we all know, prion diseases, caused by the body's own proteins, are invariably fatal and highly infectious neurodegenerative diseases effecting humans and almost all animals for a major public health concern. Prion contains no nucleic acids and it is a misshapen or conformation-changed protein that acts like an infectious agent; thus prion diseases are called "protein structural conformational" diseases.§§PrP C is predominant in -helices but PrP Sc are rich in -sheets in the form as amyloid fibrils; so very amenable to be studied by MD techniques. Through MD, studies on the protein structures and the structural conversion are very important for revealing secrets of prion diseases and for structure-based drug design or discovery. Rabbits, dogs, horses and buffaloes are reported to be the few low susceptibility species to prion diseases; this book's MD studies on these species are clearly helpful to understand the mechanism underlying the resistance to prion diseases. PrP(1-120) usually has no clear molecular structures; this book also studies this unstructured region through MD and especially MM techniques from the global optimization point of view.§§This book is ideal for practitioners in computing of biophysics, biochemistry, biomedicine, bioinformatics, cheminformatics, materials science and engineering, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.§
Perspectives in Modern Project Scheduling Springer, Berlin
Książki / Literatura obcojęzyczna
Operations Research began as a field with the mathematical scheduling of a massive project logistically supplying Europe with military equipment and goods during the 2nd World War. Today project scheduling research continues to grow in the variety of its theoretical models, in its magnitude, and in its application. As the world becomes more interrelated and complex, the wider its research is applied to an increasing number of project scheduling problems. §The book surveys the current state-of-the-art in this realm of operations research with chapters written by the respective leading experts on each topic. It will cover the range of the key models in the field, including deterministic, probabilistic, single- and multi-mode, single- and multi-objective, and a general model on discrete-continuous resources. Recent solution algorithms are systematically examined. The book summarizes the current developments and theoretical achievements in the field. These new developments include project uncertainty and grid resource management. §PERSPECTIVES IN MODERN PROJECT SCHEDULING systematically presents this dynamically developing area in three parts. Part I discusses new models of the project management process that are being developed. They include an alternative to the well-known PERT technique, consideration of disturbances during the project realization, introduction of new constraints like due dates or setup times, as well as a general discussion on classification of resources. §Part II outlines and evaluates the new algorithms that have been developed to solve the strongly NP-hard resource constrained project scheduling efficiently with acceptable accuracy. New lower bounds for the RCPSP are proposed, followed by smart justification technique and a series of Metaheuristics. Finally, a neural network approach is introduced.§Part III is devoted to new areas of applications of the project management models and the algorithms for example, pharmaceutical research, grid computing, factory pick-up of new cars, batch scheduling in process industries and make-to-order (project driven) manufacturing that have been developed to solve project scheduling problems in these application areas.§The book will be of interest to academics and students in project management and scheduling in Business Schools, Operations Research/Management Science, Computer Science & Engineering, Systems Analysis, and Applied Mathematics. In addition, decision makers, consultants and practitioners in industry, government and service organizations will also be interested in this book.
Cryptography and Secure Communication Cambridge University Press
Today's pervasive computing and communications networks have created an intense need for secure and reliable cryptographic systems. Bringing together a fascinating mixture of topics in engineering, mathematics, computer science, and informatics, this book presents the timeless mathematical theory underpinning cryptosystems both old and new. Major branches of classical and modern cryptography are discussed in detail, from basic block and stream cyphers through to systems based on elliptic and hyperelliptic curves, accompanied by concise summaries of the necessary mathematical background. Practical aspects such as implementation, authentication and protocol-sharing are also covered, as are the possible pitfalls surrounding various cryptographic methods. Written specifically with engineers in mind, and providing a solid grounding in the relevant algorithms, protocols and techniques, this insightful introduction to the foundations of modern cryptography is ideal for graduate students and researchers in engineering and computer science, and practitioners involved in the design of security systems for communications networks.
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