krainaksiazek computational drug discovery drug discovery process methods 20092415

- znaleziono 10 produkty w 3 sklepach

Computational and Structural Approaches to Drug Discovery - 2826661022

1058,09 zł

Computational and Structural Approaches to Drug Discovery Royal Society Of Chemistry

Książki / Literatura obcojęzyczna

Computational methods impact all aspects of modern drug discovery and most notably these methods move rapidly from academic exercises to becoming drugs in clinical trials...This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the factors that determine adsorption, distribution, metabolism, excretion and toxicology are explored, as they remain the critical issues in this area of research. This indispensable resource provides the reader with: * A rich understanding of modern approaches to docking * A comparison and critical evaluation of state-of-the-art methods * Details on harnessing computational methods for both analysis and prediction * An insight into prediction potencies and protocols for unbiased evaluations of docking and scoring algorithms * Critical reviews of current fragment based methods with perceptive applications to kinases Addressing a wide range of uses of protein structures for drug discovery the Editors have created and essential reference for professionals in the pharmaceutical industry and moreover an indispensable core text for all graduate level courses covering molecular interactions and drug discovery.

Sklep: Libristo.pl

Bioinformatics And Computational Biology In Drug Discovery And Development - 2846073420

319,99 zł

Bioinformatics And Computational Biology In Drug Discovery And Development

Książki Obcojęzyczne>Nieprzypisane

A Comprehensive Overview Of The Use Of Computational Biology Approaches In The Drug Discovery And Development Process.

Sklep: Gigant.pl

Systems Biology in Drug Discovery and Development - 2845097949

442,23 zł

Systems Biology in Drug Discovery and Development Wiley & Sons

Książki / Literatura obcojęzyczna

The first book to focus on comprehensive systems biology as applied to drug discovery and development§Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries.§The first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification.§Introducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.

Sklep: Libristo.pl

Protein-Protein Interactions in Drug Discovery - 2852642025

764,40 zł

Protein-Protein Interactions in Drug Discovery Wiley

Książki / Literatura obcojęzyczna

Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation. §The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as cancer, autoimmune disorders and infectious diseases. Tailor-made for the practicing medicinal chemist, this ready reference includes a wide selection of case studies taken straight from the development pipeline of major pharmaceutical companies to illustrate the power and potential of this approach.

Sklep: Libristo.pl

Structure/Ligand-based Drug Design and Structure Bioinformatics - 2835279160

314,61 zł

Structure/Ligand-based Drug Design and Structure Bioinformatics VDM Verlag Dr. Müller

Książki / Literatura obcojęzyczna

Drug discovery and development is a very expensive§and time-consuming process. To improve the §efficiency of the pipeline, Computer-Aided Drug§Design (CADD) has become increasingly important over§the years. CADD represents an interplay paradigm§between in-depth in silico studies and the follow-up§wet-lab validations. However we have not achieved§true synergy among various computational§subdisciplines, such as cheminformatics and§bioinformatics. This book, therefore, focuses on the§design, development and applications of novel§approaches for CADD and protein structure§bioinformatics. These approaches were developed in§the areas of both ligand-based and structure-based§drug design. In addition, Simplicial Neighborhood§Analysis of Protein Packing (SNAPP) has been§employed for the analysis of protein flexibility.§This has resulted in powerful and cutting-edge§computational tools for the rational drug design and§the prediction of unintuitive consequences of§targeted therapeutics. The work should help shed§some light on this exciting field, and should be§especially useful to professionals in computational§drug discovery and other biomedical research-related §areas.

Sklep: Libristo.pl

Protein Tyrosine Kinases - 2847848034

1214,19 zł

Protein Tyrosine Kinases Springer, Berlin

Książki / Literatura obcojęzyczna

Leading researchers, from the Novartis group that pioneered Gleevec/Glivec and around the world, comprehensively survey the state of the art in the drug discovery processes (bio- and chemoinformatics, structural biology, profiling, generation of resistance, etc.) aimed at generating PTK inhibitors for the treatment of various diseases, including cancer. Highlights include a discussion of the rationale and the progress made towards generating "selective" low molecular-weight kinase inhibitors; an analysis of the normal function, role in disease, and application of platelet-derived growth factor antagonists; and a summary of the factors involved in successful structure-based drug design. Additional chapters address the advantages and disadvantages of in vivo preclinical models for testing protein kinase inhibitors with antitumor activity and the utility of different methods in the drug discovery and development process for determining "on-target" vs "off-target" effects of kinase inhibitors.Protein kinases function as components of signal transduction pathways, playing a central role in the control of cell growth, metabolism, differentiation, and apoptosis. The development of selective protein tyrosine kinase (PTK) inhibitors that can block or modulate diseases, such as cancer, with abnormalities in these signaling pathways is considered a promising approach for drug development. Currently, more than 20 different PTKs are being considered as potential therapeutic targets in oncology. In Protein Tyrosine Kinases: From Inhibitors to Useful Drugs, leading researchers from the Novartis group that pioneered Gleevec/Glivec and from around the world comprehensively survey the state-of-the-art in the drug discovery processes (bio- and chemoinformatics, structural biology, profiling, generation of resistance, etc.) aimed at generating PTK inhibitors for the treatment of various diseases, including cancer. Highlights include a discussion of the rationale and the progress made toward generating "selective" low molecular-weight kinase inhibitors; an analysis of the normal function, role in disease, and application of platelet-derived growth factor antagonists; and a summary of the factors involved in successful structure-based drug design. Additional chapters address the advantages and disadvantages of in vivo preclinical models for testing PTK inhibitors with antitumor activity and the utility of different methods in the drug discovery and development process for determining "on-target" vs "off-target" effects of kinase inhibitors. §Authoritative and state-of-the-art, Protein Tyrosine Kinases: From Inhibitors to Useful Drugs details the key stages in the design of PTK inhibitors and their development into useful drugs.

Sklep: Libristo.pl

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 1 - 2826758346

1222,56 zł

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 1 Springer, Berlin

Książki / Literatura obcojęzyczna

There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics , leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer.§Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs.§Road map to anticancer drug development from discovery to NDA submission §Discussion of molecular targets and preclinical screening §Development and validation of bioanalytical methods §Chapters on clinical trial design and phase 0, I, II, III clinical trials §Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents §Review of the drug development process from both laboratory and clinical perspectives §New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development

Sklep: Libristo.pl

Protein Tyrosine Kinases - 2212827047

549,80 zł

Protein Tyrosine Kinases Humana Press

Zdrowie, medycyna

Leading researchers, from the Novartis group that pioneered Gleevec/Glivec

Sklep: Albertus.pl

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics - 2841436326

1315,90 zł

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics Springer, Berlin

Książki / Literatura obcojęzyczna

Leading investigators synthesize the entire laboratory and clinical process of developing anticancer drugs to create a single indispensable reference that covers all the steps from the identification of cancer-specific targets to phase III clinical trials. These expert authors provide their best guidance on a wide variety of issues, including clinical trial design, preclinical screening, and the development and validation of bioanalytic methods. The chapters on identifying agents to test in phase III trials and on trial design for the approval of new anticancer agents offer a unique roadmap for moving an agent to NDA submission.There are many steps on the road from discovery of an anticancer drug to securing its final approval by the U. S. Food and Drug Administration (FDA). In Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes that lead to anticancer drugs, creating a single indispensable reference that covers all the steps from the identification of cancer-specific targets to phase III clinical trials. These expert authors provide their best guidance on a wide variety of issues, including clinical trial design, preclinical screening, and the development and validation of bioanalytic methods. They detail each step in the process, ranging from compound design and synthesis, screening techniques using in vitro models, and SAR analysis for lead optimization, to in vivo experiments, formulation, preclinical pharmacokinetics, formal toxicology, and phase I, II, and III trials. The chapters on identifying agents to test in phase III trials and on trial design for the approval of new anticancer agents offer a unique road map for moving an agent to NDA submission. §Comprehensive and highly practical, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics provides in one volume a detailed step-by-step guide to the successful design and approval of anticancer drugs.

Sklep: Libristo.pl

Handbook of Pharmaceutical Biotechnology - 2212833173

708,30 zł

Handbook of Pharmaceutical Biotechnology John Wiley & Sons

Inne 1

A practical overview of a full rangeof approaches to discovering, selecting, and producing biotechnology-derived drugs The Handbook of Pharmaceutical Biotechnology helps pharmaceutical scientists develop biotech drugs through a comprehensive framework that spans the process from discovery, development, and manufacturing through validation and registration. With chapters written by leading practitioners in their specialty areas, this reference: Provides an overview of biotechnology used in the drug development process Covers extensive applications, plus regulations and validation methods Features fifty chapters covering all the major approaches to the challenge of identifying, producing, and formulating new biologically derived therapeutics With its unparalleled breadth of topics and approaches, this handbook is a core reference for pharmaceutical scientists, including development researchers, toxicologists, biochemists, molecular biologists, cell biologists, immunologists, and formulation chemists. It is also a great resource for quality assurance/assessment/control managers, biotechnology technicians, and others in the biotech industry.

Sklep: Albertus.pl

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