krainaksiazek computational drug discovery drug discovery process methods 20092415

- znaleziono 14 produktów w 4 sklepach

Bioinformatics And Computational Biology In Drug Discovery And Development - 2846073420

319,99 zł

Bioinformatics And Computational Biology In Drug Discovery And Development

Książki Obcojęzyczne>Nieprzypisane

A Comprehensive Overview Of The Use Of Computational Biology Approaches In The Drug Discovery And Development Process.

Sklep: Gigant.pl

Multifaceted Roles of Crystallography in Modern Drug Discovery - 2854228300

424,33 zł

Multifaceted Roles of Crystallography in Modern Drug Discovery Springer Netherlands

Książki / Literatura obcojęzyczna

In the past years we have seen great progress in the fields of genetics, biology, and medicine, but there are still many unmet medical needs, from bacterial infections to cancer to chronic maladies, that require novel, different, or better therapies. Approaches to drug discovery have changed over time, and so have the methodologies used, in order to solve the varied, new, and difficult problems that may happen in the path to drug discovery. Together with experimental techniques, a variety of computational approaches have been applied at various stages of the drug-design process, and for the past two decades structure-based drug design has become one of the mainstream approaches. This method can be used to target protein-ligand and protein-protein interactions and nowadays is applicable to all aspects of drug discovery, including lead identification, lead optimization, ADMET prediction and drug repurposing. This book presents a snapshot of the state of the art of crystallographic, analytical, and computational methods used in modern drug design and development. These methods are illustrated through their application to problems of great medical and biological significance, such as viral infections, diabetes, and targeting of membrane proteins. §

Sklep: Libristo.pl

Multi-Scale Approaches in Drug Discovery - 2854525659

739,30 zł

Multi-Scale Approaches in Drug Discovery ELSEVIER SCIENCE

Książki / Literatura obcojęzyczna

Multi-Scale Approaches to Drug Discovery: From Empirical Knowledge to In Silico Experiments and Back furnishes chemists with the detail they need to identify drug leads with the highest potential before isolating and synthesizing them to produce effective drugs with greater swiftness than classical methods may allow. This significantly speeds up the search for more efficient therapeutic agents. After an introduction to multiscale approaches that outline the need for, and benefits of, their use, the book goes on to explore a range of useful techniques, research areas, and their potential applications to this process. Activity cliffs in drug discovery, computational biology in drug discovery, and the use of a novel multitasking chemo-bioinformatic models to speed up the discovery of potent and safer antibacterial peptides are all discussed before the book goes on to review drug and gene delivery, Nano-QSAR in drug discovery, medicinal chemistry, computational approaches in peptide discovery, and the design of multi-target drugs/ligands against neurodegenerative disorders.

Sklep: Libristo.pl

Organic Chemistry of Drug Design and Drug Action - 2854244525

377,44 zł

Organic Chemistry of Drug Design and Drug Action ACADEMIC PRESS

Książki / Literatura obcojęzyczna

The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows the reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition reflects significant changes in the process of drug design over the last decade. It preserves the successful approach of the previous editions while including significant changes in format and coverage. New to this edition: * Updates to all chapters, including new examples and references* Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book* Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry* Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant* Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis* Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: * for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib* for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid* for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin* Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples* Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites* Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody-drug conjugates

Sklep: Libristo.pl

Drug Discovery Toxicology - 2854434095

823,91 zł

Drug Discovery Toxicology John Wiley & Sons Inc

Książki / Literatura obcojęzyczna

As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. * Guides researchers as to what drug safety experiments are both practical and useful * Covers a variety of key topics - safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and -omics tools * Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods * Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices

Sklep: Libristo.pl

Basic Principles of Drug Discovery and Development - 2854338761

343,66 zł

Basic Principles of Drug Discovery and Development Academic Press Inc

Książki / Literatura obcojęzyczna

Basic Principles of Drug Discovery and Development explains that identifying a new drug in the modern era is a multifaceted endeavor that requires a multidisciplinary team approach. It also describes enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine that have become critical to the successful development of marketable therapeutics. This book introduces the fundamental principles of drug discovery and development, beginning with an historical overview of drug discovery. It then educates readers about important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable a new scientist to rapidly understand the key fundamentals of drug discovery including pharmacokinetics, toxicology, and intellectual property, to fill knowledge gaps that could lead to communication issues. * Clearly explains the complete drug discovery process from obtaining a lead to testing the bioactivity, to producing the drug and protecting the intellectual property* Designed for everyone learning about or thinking of entering the drug discovery space (and transitioning from academia to industry or from another industry to pharma)* Simply presents and describes how the pharmaceutical industry works

Sklep: Libristo.pl

Drug-Like Properties - 2854442706

711,26 zł

Drug-Like Properties ELSEVIER SCIENCE

Książki / Literatura obcojęzyczna

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistryIncludes expanded coverage of pharmacokinetics fundamentals and effectsContains updates throughout, including the authorsâ

Sklep: Libristo.pl

DISCOVERY - 48 GODZIN Z BEAREM GRYLLSEM (2DVD) - 2836911812

29,70 zł

DISCOVERY - 48 GODZIN Z BEAREM GRYLLSEM (2DVD)

Książki & Multimedia > Filmy Video

Opis - Bear Grylls, ekspert w dziedzinie sztuki przetrwania i niekwestionowana gwiazda Discovery Channel powraca do akcji - tym razem w towarzystwie

Sklep: InBook.pl

Pharmacology Primer - 2854203344

428,10 zł

Pharmacology Primer ACADEMIC PRESS

Książki / Literatura obcojęzyczna

§A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, 4 th Edition features the latest ideas and research about the application of pharmacology to the process of drug discovery to equip readers with a deeper understanding of the complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This edition has been thoroughly revised to include material on data-driven drug discovery, biased signaling, structure-based drug design, drug activity screening, drug development (including pharmacokinetics and safety Pharmacology), and much more. With more color illustrations, examples, and exercises throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery, or pharmacologic research. §Highlights changes surrounding the strategy of drug discovery to provide you with a comprehensive reference featuring advances in the methods involved in lead optimization and more effective drug discovery §Includes a new chapter on data-driven drug discovery in terms of the optimal design of pharmacological experiments to identify mechanism of action of new molecules §Illustrates the application of rapid inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data

Sklep: Libristo.pl

Handbook of Medicinal Chemistry - 2854245329

448,76 zł

Handbook of Medicinal Chemistry Royal Society Of Chemistry

Książki / Literatura obcojęzyczna

Drug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry covers the past, present and future of the entire drug development process. Highlighting the recent successes and failures in drug discovery, the book will help readers to understand the factors governing modern drug discovery from the initial concept through to a marketed medicine. With chapters covering a wide range of topics from drug discovery processes and optimization, development of synthetic routes, pharmaceutical properties and computational biology, the handbook aims to help medicinal chemists to apply their academic understanding to every aspect of drug discovery. Each chapter includes expert advice to not only provide a rigorous understanding of the principles being discussed, but to provide useful hints and tips gained from within the pharmaceutical industry. This expertise, combined with project case studies, highlighting and discussing all areas of successful projects, make this an essential handbook for all those involved in pharmaceutical development.

Sklep: Libristo.pl

Essentials of Botanical Extraction - 2854358650

322,02 zł

Essentials of Botanical Extraction ACADEMIC PRESS

Książki / Literatura obcojęzyczna

Essentials of Botanical Extraction: Principles and Applications provides a unique, single source of valuable information on the various botanical extraction methods available, from conventional to the use of green and modern extraction technologies including ultrasounds, microwaves, pressurized liquids, and supercritical fluids. Most extracts obtained from botanicals are often poorly characterized with unidentified active or inactive constituents. A wise selection of an extraction strategy is vital to drug discovery from medicinal plants as extraction forms the basic first step in medicinal plant research. This book also explores the mathematical hypotheses and innovations in botanical extractions and analyzes different post extraction operations so that dependency on serendipity is reduced and the same be converted into programmed drug discovery.§§Reviews the history and current state of natural product drug discovery and development, highlighting successes and current issues§Explains the application of chemometric tools in extraction process design and method development§Introduces process intensification as applied to the processing of medicinal plant extracts for rapid and cost-effective extraction

Sklep: Libristo.pl

Protein Tyrosine Kinases - 2212827047

549,80 zł

Protein Tyrosine Kinases Humana Press

Zdrowie, medycyna

Leading researchers, from the Novartis group that pioneered Gleevec/Glivec

Sklep: Albertus.pl

Clustering Analysis in Bioinformatics - 2854333581

462,04 zł

Clustering Analysis in Bioinformatics Wiley-Blackwell (an imprint of John Wiley & Sons...

Książki / Literatura obcojęzyczna

Clustering techniques are increasingly being put to use in the analysis of high-throughput biological datasets. Novel computational techniques to analyse high throughput data in the form of sequences, gene and protein expressions, pathways, and images are becoming vital for understanding diseases and future drug discovery. This book details the complete pathway of cluster analysis, from the basics of molecular biology to the generation of biological knowledge. The book also presents the latest clustering methods and clustering validation, thereby offering the reader a comprehensive review of clustering analysis in bioinformatics from the fundamentals through to state-of-the-art techniques and applications. It offers a contemporary review of clustering methods and applications in the field of bioinformatics, with particular emphasis on gene expression analysis. It provides an excellent introduction to molecular biology with computer scientists and information engineering researchers in mind, laying out the basic biological knowledge behind the application of clustering analysis techniques in bioinformatics. It explains the structure and properties of many types of high-throughput datasets commonly found in biological studies. It discusses how clustering methods and their possible successors would be used to enhance the pace of biological discoveries in the future. It includes a companion website hosting a selected collection of codes and links to publicly available datasets.

Sklep: Libristo.pl

Handbook of Pharmaceutical Biotechnology - 2212833173

708,30 zł

Handbook of Pharmaceutical Biotechnology John Wiley & Sons

Inne 1

A practical overview of a full rangeof approaches to discovering, selecting, and producing biotechnology-derived drugs The Handbook of Pharmaceutical Biotechnology helps pharmaceutical scientists develop biotech drugs through a comprehensive framework that spans the process from discovery, development, and manufacturing through validation and registration. With chapters written by leading practitioners in their specialty areas, this reference: Provides an overview of biotechnology used in the drug development process Covers extensive applications, plus regulations and validation methods Features fifty chapters covering all the major approaches to the challenge of identifying, producing, and formulating new biologically derived therapeutics With its unparalleled breadth of topics and approaches, this handbook is a core reference for pharmaceutical scientists, including development researchers, toxicologists, biochemists, molecular biologists, cell biologists, immunologists, and formulation chemists. It is also a great resource for quality assurance/assessment/control managers, biotechnology technicians, and others in the biotech industry.

Sklep: Albertus.pl

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