krainaksiazek design and development of novel anticoagulant agents 20124094

- znaleziono 3 produkty w 1 sklepie

Novel syntheses of the benzoquinones Idebenone and CoQ10 - 2836771625

376,97 zł

Novel syntheses of the benzoquinones Idebenone and CoQ10 LAP Lambert Academic Publishing

Książki / Literatura obcojęzyczna

The topic of this project is related to the investigation, design and development of novel synthetic methods and pathways to natural antioxidants and their synthetic analogues that can be utilized as pharmaceuticals, nutraceuticals and preservation agents for food and feed, particularly marine lipids. Distinctive interest is paid to the development and exploration of phenolic and benzoquinone class of compounds such as coenzyme Q10 (CoQ10) and Idebenol. Focal point is the development of practical, efficient, and cost-effective synthetic methods and pathways that will employ cheap and readily available materials, and "green" conditions and reagents. A novel total synthesis to Idebenone is concluded while the development of a synthetic path leading to CoQ10 has also been explored. Among the deliverables are: a) a novel green bromination protocol for activated arenes b) an oxidation protocol leading to two versatile intermediates c) a purification protocol of Heck coupling post-reaction mixtures for transition metal catalyst based on organic solvent nanofiltration and d) a palladium catalyzed Heck coupling protocol performed under microwave irradiation.


Interactions of Flavones and Related Compounds with Nucleic Acids - 2846872277

522,06 zł

Interactions of Flavones and Related Compounds with Nucleic Acids VDM Verlag Dr. Müller

Książki / Literatura obcojęzyczna

Across the world, different diseases have been§treated with herbal extracts, based on common and§empiric knowledge. The process of identification of§the active compounds and their synthesis,§optimisation and development for new drug candidates§appropriate for clinical use is described as§Medicinal Chemistry; a discipline merging chemistry§and pharmacology. §This monograph describes a group of active§ingredients from herbal medicines, as a foundation§for the development of new anticancer drugs.§Interactions between with genomic DNA, synthetic§polynucleotides and higher order DNA isoforms (triple§and quadruple helical forms) have been studied.§Rational drug design has been also employed during§this project to elucidate the mode of binding and§novel compounds have been synthesized to provide§precise structure-activity related studies resulting§in a second generation of chemotherapeutic anticancer§agents with improved properties. §This book provides information and protocols for§studying drug-DNA interactions using spectroscopical§and biological techniques; synthesis of flavonoids§and the principles to explore the use of Quantitative§Structure Activity Relationship Studies.


Lasso Peptides, 1 - 2837118214

256,47 zł

Lasso Peptides, 1 Springer, Berlin

Książki / Literatura obcojęzyczna

Lasso peptides form a growing family of fascinating ribosomally-synthesized and post-translationally modified peptides produced by bacteria. They contain 15 to 24 residues and share a unique interlocked topology that involves an N-terminal 7 to 9-residue macrolactam ring where the C-terminal tail is threaded and irreversibly trapped. The ring results from the condensation of the N-terminal amino group with a side-chain carboxylate of a glutamate at position 8 or 9, or an aspartate at position 7, 8 or 9. The trapping of the tail involves bulky amino acids located in the tail below and above the ring and/or disulfide bridges connecting the ring and the tail. Lasso peptides are subdivided into three subtypes depending on the absence (class II) or presence of one (class III) or two (class I) disulfide bridges. The lasso topology results in highly compact structures that give to lasso peptides an extraordinary stability towards both protease degradation and denaturing conditions. Lasso peptides are generally receptor antagonists, enzyme inhibitors and/or antibacterial or antiviral (anti-HIV) agents. The lasso scaffold and the associated biological activities shown by lasso peptides on different key targets make them promising molecules with high therapeutic potential. Their application in drug design has been exemplified by the development of an integrin antagonist based on a lasso peptide scaffold. The biosynthesis machinery of lasso peptides is therefore of high biotechnological interest, especially since such highly compact and stable structures have to date revealed inaccessible by peptide synthesis. Lasso peptides are produced from a linear precursor LasA, which undergoes a maturation process involving several steps, in particular cleavage of the leader peptide and cyclization. The post-translational modifications are ensured by a dedicated enzymatic machinery, which is composed of an ATP-dependent cysteine protease (LasB) and a lactam synthetase (LasC) that form an enzymatic complex called lasso synthetase. Microcin J25, produced by Escherichia coli AY25, is the archetype of lasso peptides and the most extensively studied. To date only around forty lasso peptides have been isolated, but genome mining approaches have revealed that they are widely distributed among Proteobacteria and Actinobacteria, particularly in Streptomyces, making available a rich resource of novel lasso peptides and enzyme machineries towards lasso topologies.§


Sklepy zlokalizowane w miastach: Warszawa, Kraków, Łódź, Wrocław, Poznań, Gdańsk, Szczecin, Bydgoszcz, Lublin, Katowice

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