krainaksiazek hepatitis b virus in human diseases 20045123

- znaleziono 16 produktów w 4 sklepach

Hepatitis B Amp Delta Viruses - 2844446703

599,99 zł

Hepatitis B Amp Delta Viruses

Książki Obcojęzyczne>Angielskie>Medicine>Clinical & internal medicine>Diseases & disorders>ImmunologyKsiążki Obcojęzyczne>Angielskie...

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Sklep: Gigant.pl

Epstein-Barr Virus and Human Disease - 2856490187

852,13 zł

Epstein-Barr Virus and Human Disease Springer, Berlin

Książki / Literatura obcojęzyczna

Since its discovery as the cause of infectious mononucleosis in 1964, the Epstein-Barr virus (EBV) has been etiologically implicated in an increasing number of human diseases. Generally considered the first human oncogenic virus because of a number of studies linking it with Burkitt's lymphoma and nasopharyngeal carcinoma (NPC), as well as its documented oncogenicity in nonhuman primates, EBVhas served as a model for identifying subsequent candidate oncogenic viruses and the stimulus for Evans' revision of the Henle-Koch postulates to accommodate the problems in proving viral oncogenicity in humans. Research on the role of EBV in human cancer was particularly en hanced (a) by the pioneering work of Werner and Gertrude Henle, and (b) by the coordinated efforts of the Special Virus Leukemia Program and its successors, the Special Virus Cancer Program and the Virus Cancer Program of the National Cancer Institute (NCI). Initiated by Dr. Frank J. Rauscher, who subsequently became director of the Ncr and is now Vice-President of the American Cancer Society, and expanded by Dr. John B. Moloney, whose contributions to cancer research were honored at this Second International Symposium on EBV and Associated Malignant Diseases, these NCI contract-sup ported programs brought together investigators from all over the world to participate in a joint effort to unravel the mystery of EBV behavior and pathogenicity. It was these programs that gave us the opportunity to work with such outstanding people as Professor Yohei Ito, to whom this book is dedicated.

Sklep: Libristo.pl

Infections & Human Cancer v.33 - 2212838356

371,50 zł

Infections & Human Cancer v.33 Cold Spring Harbor Laboratory Press

Zdrowie, medycyna

In the opening chapter of Infections and Human Cancer, Parkin and colleagues estimate that in 1990 there were 1.2 million new cases of cancer worldwide that were due to infectious agents. This figure accounts for about 15 percent of all cancers. These cases plus the sum of all neoplasms caused by tobacco account for the largest number of preventable cancers in the world. Infectious agents cause almost one fourth of all cancers in developing countries, a reflection of the high carrier rates in these regions for the four agents that cause 90 percent of cancers due to persistent infection: the hepatitis B and C viruses, the human papilloma viruses, and Helicobacter pylori. Microbial carcinogenesis is, for these reasons, a major public health problem. Its solution will require a huge investment of resources, almost all of it by industrialized countries. Moreover, neoplastic diseases evoked by persistent infection are no longer unusual in developed nations, as evidenced by the rising incidence of hepatocellular carcinoma in the United States, the high prevalence of papillomavirus infection among women, and the frequent occurrence of virus-induced cancers, such as Kaposi's sarcoma and B-cell lymphomas, in patients with AIDS. These facts make a compelling argument that physicians everywhere must understand the clinical implications of persistent infection with potentially oncogenic microbes, the advantages and limitations of screening for such infections and the cancers they cause, and the measures that are at hand or will be available to prevent the spread of these organisms. The two books reviewed here survey the epidemiologic evidence linking a variety of microbes to the causation of cancer, analyze the molecular mechanisms of microbial carcinogenesis, and discuss measures to thwart infection-associated cancer. The organisms under scrutiny include the human papillomaviruses, Epstein-Barr virus, human herpesvirus 8 (HHV-8, or Kaposi's sarcoma-associated herpesvirus), hepatitis B and C viruses, human T-cell leukemia virus, schistosoma, liver flukes, H. pylori, and intestinal bacteria. Each book features concise, timely expositions of various aspects of microbial oncogenesis, from descriptions of the culpable organisms to prevention by vaccination. Despite their similarities, these books differ in outlook and tone. For readers seeking a comprehensive review of the problems of infection-related cancer, both are worth examining. Infections and Human Cancer offers 15 surveys of the epidemiology, risk factors, and molecular mechanisms of carcinogenic microorganisms. The review of cancer in patients infected with the human immunodeficiency virus is excellent. A chapter on screening points out that the administration of hepatitis B immunoglobulin to newborns of infected mothers immediately after birth can reduce the carrier rate in children by as much as 90 percent. Presumably, the institution of national or worldwide programs of such prophylactic passive immunization against the hepatitis B virus will ultimately reduce the prevalence of hepatocellular carcinoma. In long-term carriers of the virus, screening with a combination of alpha-fetoprotein measurement and hepatic ultrasonography shows promise in detecting early, surgically resectable tumors. For hepatitis C, unfortunately, there is no effective means of prophylaxis, rendering moot the issue of screening until prevention is practical. Infections and Human Cancer concludes with a chapter on prophylactic and therapeutic vaccination against hepatitis B, human papillomaviruses, and H. pylori. Some of these vaccines are still in developmental stages; if they prove to be safe, effective, and economically feasible, they promise enormous benefits. Parsonnet leads off Microbes and Malignancy with a brief account of the history of the relation between infectious diseases and cancer. She places Leeuwenhoeck, who was born in 1632, in the 19th century and fails to mention Gross's seminal discovery of the mouse leukemia virus. However, she effectively relates how the history of cancer research was marred by false starts (notably Fibiger's mistaken claim that a nematode can cause stomach cancer, for which he was awarded the Nobel prize) and doubts that any organism could cause cancer (Rous had to wait more than 50 years before he was awarded the Nobel prize for his discovery of the chicken sarcoma virus). The first four chapters of Microbes and Malignancy deal with mechanisms of infection-induced cancer. Relman's review of chronic host-parasite interactions has a broad sweep, whereas the chapter on chronic inflammation and cancer focuses narrowly on the role of oxidative damage. Cohen reviews the evidence implicating cell proliferation in the pathogenesis of cancer but says little about DNA repair (defective DNA repair in ataxia-telangiectasia is well covered later by Karp and Blattner) or the chromosomal aberrations that are at least as essential to cell transformation as proliferation. In his excellent chapter on viral oncogenesis, Zur Hausen traces the evolution of cancer from infection with a carcinogenic human papillomavirus, through the loss of the cellular genes required to counteract the growth-promoting effects of papillomavirus oncoproteins, to the escape of the transformed cell from attack by the immune system. Microbes and Malignancy offers thorough reviews of the diseases caused by the Epstein-Barr virus, HHV-8, the hepatitis B and C viruses, H. pylori, and other relevant microbes. For readers interested in other microbial causes of cancer, there are informative reviews of the T-cell leukemia virus, schistosomes, and liver flukes. Robinson points out that, worldwide, only the number of lung cancers due to cigarette smoking exceeds the incidence of hepatocellular carcinoma due to hepatitis B virus. According to Parsonnet, about half the world's population harbors H. pylori, yet in only 1 percent does gastric cancer develop. Gastric lymphoma is even rarer, and it occasionally occurs simultaneously with gastric cancer. Infections and Human Cancer and Microbes and Malignancy are fascinating books, and like all good surveys of scientific matters, they raise profound questions for which there are no immediate answers. A thread running through both books is that despite its immense power to give us a close-up view of how cancer develops, molecular biology cannot show us the big picture. Until we find new ways of looking at the connections between microbes and cancer, we will remain, as Milton said in Comus, 'in the blind mazes of this tangled wood.'

Sklep: Albertus.pl

Epstein Barr Virus Vol. 1 - 2843286441

720,74 zł

Epstein Barr Virus Vol. 1 Springer, Berlin

Książki / Literatura obcojęzyczna

Epstein Barr virus (EBV) was discovered as the first human tumor virus around 50 years ago. Since its discovery in Burkitt's lymphoma it has been associated with various other malignancies, infectious mononucleosis and even autoimmune diseases. The two book volumes on EBV summarize the first 50 years of research on this tumor virus, starting with historical perspectives on discovery, oncogenicity and immune control, reviewing the role that the virus plays in the various associated diseases and concluding with a discussion on how the immune system keeps persistent EBV infection under control in healthy EBV carriers and can be used to treat EBV associated diseases. The respective 32 chapters are written by international experts from three continents for health care providers, biomedical researchers and patients that are affected by EBV. The assembled knowledge should help to understand EBV associated diseases better and to develop EBV specific vaccination in the near future.

Sklep: Libristo.pl

Epstein Barr Virus Vol. 2 - 2854483470

720,74 zł

Epstein Barr Virus Vol. 2 Springer, Berlin

Książki / Literatura obcojęzyczna

Epstein Barr virus (EBV) was discovered as the first human tumor virus around 50 years ago. Since its discovery in Burkitt's lymphoma it has been associated with various other malignancies, infectious mononucleosis and even autoimmune diseases. The two book volumes on EBV summarize the first 50 years of research on this tumor virus, starting with historical perspectives on discovery, oncogenicity and immune control, reviewing the role that the virus plays in the various associated diseases and concluding with a discussion on how the immune system keeps persistent EBV infection under control in healthy EBV carriers and can be used to treat EBV associated diseases. The respective 32 chapters are written by international experts from three continents for health care providers, biomedical researchers and patients that are affected by EBV. The assembled knowledge should help to understand EBV associated diseases better and to develop EBV specific vaccination in the near future.

Sklep: Libristo.pl

Assisted Reproductive Technologies and Infectious Diseases - 2854448955

350,15 zł

Assisted Reproductive Technologies and Infectious Diseases Springer, Berlin

Książki / Literatura obcojęzyczna

This concise and practical book is the first of its kind to examine the use of assisted reproductive technologies (ART) in relation to blood-borne infectious diseases: human immunodeficiency virus (HIV), hepatitis B (HBV) and hepatitis C (HCV). The book opens with a discussion of the impact of these viruses on male and female fertility, followed by specific chapters of each of them, including ART with HIV and HCV serodiscordant couples (where either the male or female is positive) and the detection and impact of HBV and HCV in human gametes and embryos. An important character on laboratory safety when performing ART with blood-borne viruses follows, and the book concludes with a discussion of ART in austere and resource-poor settings, where these infections are often dominant due to lack of treatment and access to vaccines. Written and edited by an international array of experts in reproductive medicine, Assisted Reproductive Technologies and Infectious Diseases explores questions, techniques, and related issues with the aim of effectively helping clinicians working with serodiscordant couples wishing to have children.§§

Sklep: Libristo.pl

Cancer Virus - 2854211251

84,40 zł

Cancer Virus Oxford University Press

Książki / Literatura obcojęzyczna

This is the story of the discovery of the first human cancer virus. Through intriguing accounts that include some remarkable characters and individual stories from around the globe - including the UK, Africa, USA, and China - it tells the story of the Epstein-Barr virus and the understanding of its connections to a variety of other diseases.

Sklep: Libristo.pl

Essential Human Virology - 2854446510

287,34 zł

Essential Human Virology ELSEVIER SCIENCE

Książki / Literatura obcojęzyczna

Essential Human Virology is written for the undergraduate level with case studies integrated into each chapter. The structure and classification of viruses will be covered, as well as virus transmission and virus replication strategies based upon type of viral nucleic acid. Several chapters will focus on notable and recognizable viruses and the diseases caused by them, including influenza, HIV, hepatitis viruses, poliovirus, herpesviruses, and emerging and dangerous viruses. Additionally, how viruses cause disease, or pathogenesis, will be highlighted during the discussion of each virus family, and a chapter on the immune response to viruses will be included. Further, research laboratory assays and viral diagnosis assays will be discussed, as will vaccines, anti-viral drugs, gene therapy, and the beneficial uses of viruses. By focusing on general virology principles, current and future technologies, familiar human viruses, and the effects of these viruses on humans, this textbook will provide a solid foundation in virology while keeping the interest of undergraduate students. Focuses on the human diseases and cellular pathology that viruses causeHighlights current and cutting-edge technology and associated issuesPresents real case studies and current news highlights in each chapterFeatures dynamic illustrations, chapter assessment questions, key terms, and summary of concepts, as well as an instructor website with lecture slides, test bank, and recommended activities

Sklep: Libristo.pl

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity - 2854349748

653,31 zł

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity ACADEMIC PRESS

Książki / Literatura obcojęzyczna

Volume 6 provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Attention is given to a number of mechanistic advances in the understanding of regulation, particularly the importance of nutrient availability; microRNAs; and cross-talk with other protein degradation pathways. Intracellular pathogen repurposing of autophagy for pathogenic benefit is also provided, with coverage of Herpesvirus protein modulation of autophagy; the varicella-zoster virus and the maintenance of homeostasis; and the relationship between autophagy and the hepatitis b virus.§§The significance of autophagy in host defense is elucidated, providing a specific focus on facilitation of antigen presentation; participation in thymic development; and the sharing of regulatory nodes with innate immunity. Selective autophagy for the degradation of mitochondria and endocytosed gap junctions are also explored.§§This book is an asset to newcomers as a concise overview of the regulation of autophagy, its role in host defense and immunity, and selective autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge.§§Volumes in the Series§§Volume 1: Molecular Mechanisms. Elucidates autophagy's association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis. Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy's effects in various cardiovascular, metabolic, and neurodegenerative disorders. Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle. Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted d

Sklep: Libristo.pl

Infectious Disease Epidemiology - 2826969620

512,03 zł

Infectious Disease Epidemiology Jones and Bartlett Publishers

Książki / Literatura obcojęzyczna

Now in its third edition, this comprehensive volume is recognized as the most authoritative review of the epidemiology of infectious disease. Divided into five sections that cover methods in infectious disease epidemiology, airborne transmission, diarrheal diseases, blood and body fluid as a reservoir of infectious diseases, vectorborne and parasite disease, the book includes 'state-of-the-art' chapters on methodological issues, pathogenesis, and comprehensive reviews of virtually all known infectious diseases. New to the Third Edition: 1. All chapters updated with significant new information 2. HIV chapter completely updated including results of trials of Male Circumcision, HIV-vaccines, female condoms, Microbicides and new drugs 3. New chapter on Infectious Disease Eradication (e.g. Smallpox, Polio, Measles) 4. New chapter on Pneumococcal Disease (with material on S. pneumonia moved from the ARI and Vaccine chapters) 5. Influenza chapter updated with new material on H1/N1 and control/prevention of Influenza during a pandemic 6. Consolidation of material from the chapters on Outbreaks and Surveillance. 7. Nosocomial Infection chapter is shortened and updated with a new section on nosocomial/community MRSA 8. Malaria chapter updated with new information on bed nets, prophylactic therapy of pregnant women and other high risk populations as well as new detailed examination of the organization, implementation, and accomplishments of the WHO-Roll-Back Malaria program; and a new description of the 5th Human Malaria parasite-P.knowlesi and its Epidemiology. 9. STD chapter is updated with new information on the rapid diagnosis of STDs using urine PCR-methods as well as new information on partner prophylacitic treatment of STDs 10. New information in Chickengunya virus, Enterovirus 71, Nipah and Hendra virus infections to the Emerging infections chapter. 11. Hepatitis chapter is revised with new information on HEV virus 12. New brief chapter discussing the various models of behavioral change that are useful in Infectious Diseases research-e.g. Health Belief model etc.

Sklep: Libristo.pl

Gene Therapy for HIV and Chronic Infections - 2854236722

296,24 zł

Gene Therapy for HIV and Chronic Infections Springer, Berlin

Książki / Literatura obcojęzyczna

This book centers on gene therapy and gene transfer approaches to prevent or treat chronic virus infections. The main focus is on the Big Three: human immunodeficiency virus (HIV-1), hepatitis B virus (HBV) and hepatitis C virus (HCV). Ample anti-HIV drugs are currently available in the clinic and the development of an effective combination therapy has dramatically improved the lifespan and quality of life of infected individuals. A similar trend can already be recognized for HBV and HCV: the development of multiple (directly acting) antiviral drugs and plans to control or even cure the infection. However, approaches that help prevent infection, or which provide long-lasting treatment (such as a cure) remain important goals. Immunization through gene transfer vehicles encoding immunogenic viral proteins shows promise in preventing infections with complex, highly variable, viruses such as HIV-1 or HCV. Gene therapy applications for virus infections have been discussed since the early 1990 s. Whereas a true cure seems difficult to achieve for HIV-1 due to its intrinsic property to deposit its genome into that of the host, such attempts may be within reach for HCV where spontaneous viral clearance occurs in a small percentage of the infected individuals. The prospect of original gene therapy approaches may provide alternative ways to reach the same endpoint by, for example, silencing of CCR5 expression post-transcriptionally. Many alternative antiviral strategies have been developed based on a variety of novel molecular methods: e.g. ribozymes. Some studies have progressed towards pre-clinical animal models and a few antiviral gene therapies have progressed towards clinical trials. This book provides an overview of this rapidly progressing field, while focusing on the interface of gene therapy and immunology/vaccinology.

Sklep: Libristo.pl

Antiviral Agents - 2854226962

566,44 zł

Antiviral Agents Birkhäuser

Książki / Literatura obcojęzyczna

The unfortunate appearance of AIDS, the manifold problems with §herpesviruses and other viruses attacking humans have led to an enormous §dynamism of worldwide research and to an immense increase in the §corresponding literature. §With this first Special Topic of the monograph series Progress in Drug §Research, the editor and the publishers undertake an effort to supply §concise reviews on virus research, especially on the development of new §and future antiviral agents in some important and widespread viral §diseases. Latest Progress in Drug Research articles dealing with new §chemotherapeutics for the treatment of the most threatening viral §diseases are presented. These very well received articles were upgraded §and supplemented with new chapters to form this actual overview of the §achievements in the respective fields of virus research. §This special volume contains six review articles covering the latest §studies on the HIV and hepatitis C and B viruses...

Sklep: Libristo.pl

Antiviral Agents - 2822222564

288,30 zł

Antiviral Agents Birkhauser

Medycyna > English Division

The unfortunate appearance of AIDS, the manifold problems with herpesviruses and other viruses attacking humans have led to an enormous dynamism of worldwide research and to an immense increase in the corresponding literature. With this first Special Topic of the monograph series Progress in Drug Research, the editor and the publishers undertake an effort to supply concise reviews on virus research, especially on the development of new and future antiviral agents in some important and widespread viral diseases. Latest Progress in Drug Research articles dealing with new chemotherapeutics for the treatment of the most threatening viral diseases are presented. These very well received articles were upgraded and supplemented with new chapters to form this actual overview of the achievements in the respective fields of virus research. This special volume contains six review articles covering the latest studies on the HIV and hepatitis C and B viruses...

Sklep: Ksiazki-medyczne.eu

Diagnostic Virology Protocols - 2854395340

994,89 zł

Diagnostic Virology Protocols Springer, Berlin

Książki / Literatura obcojęzyczna

A collection of cutting-edge techniques for detecting most of the major viruses that afflict mankind, including influenza, hepatitis, herpes, polio, mumps, HIV, and many more. The techniques are well-tested, easily reproducible, and readily employ all the new technologies-PCR, RIA, ELISA, and latex-agglutination-that have revolutionized the field. These methods not only make it possible to do the necessary analysis in hours instead of days, but can also be automated in a laboratory havng only low levels of biological containment. Frequently, the protocols for viruses causing human diseases can be adapted to similar viruses of veterinary importance. Through its state-of-the-art methods a physician can, for the first time, determine early in a viral infection which antiviral drug should be used and minimize the period of treatment to avoid unnecessary side effects.

Sklep: Libristo.pl

Adverse Effects of Vaccines - 2854256136

282,23 zł

Adverse Effects of Vaccines National Academy Press

Książki / Literatura obcojęzyczna

In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma. Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.

Sklep: Libristo.pl

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