Manipulating the Mouse Embryo: A Laboratory Manual, Fourth Edition Cold Spring Harbor Laboratory Press,U.S.

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This 4th edition of the "Mouse Manual"-Manipulating the Mouse Embryo-appears 28 years after the first edition and once again is the definitive reference source on mouse development, transgenesis techniques, and molecular biology. While many of the

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Crispr-Cas: A Laboratory Manual Cold Spring Harbor Laboratory Press,U.S.

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The development of CRISPR-Cas technology is revolutionizing biology. Based on machinery bacteria use to target foreign nucleic acids, these powerful techniques allow investigators to edit nucleic acids and modulate gene expression more rapidly and accurate

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DNA Science: A First Course, Second Edition Cold Spring Harbor Laboratory Press,U.S.

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This is the second edition of a highly successful textbook (over 50,000 copies sold) in which a highly illustrated, narrative text is combined with easytouse thoroughly reliable laboratory protocols. It contains a fully uptodate collection of 12 rigorously

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Molecular Cloning Cold Spring Harbor Laboratory Press,U.S.

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Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years. No other manual has been so popular, or so influential. Molecular Cloning, Fourth Edition, by the celebrated founding author Joe Sambrook and new co-author, the distinguished HHMI investigator Michael Green, preserves the highly praised detail and clarity of previous editions and includes specific chapters and protocols commissioned for the book from expert practitioners at Yale, U Mass, Rockefeller University, Texas Tech, Cold Spring Harbor Laboratory, Washington University, and other leading institutions. The theoretical and historical underpinnings of techniques are prominent features of the presentation throughout, information that does much to help trouble-shoot experimental problems. For the fourth edition of this classic work, the content has been entirely recast to include nucleic-acid based methods selected as the most widely used and valuable in molecular and cellular biology laboratories. Core chapters from the third edition have been revised to feature current strategies and approaches to the preparation and cloning of nucleic acids, gene transfer, and expression analysis. They are augmented by 12 new chapters which show how DNA, RNA, and proteins should be prepared, evaluated, and manipulated, and how data generation and analysis can be handled. The new content includes methods for studying interactions between cellular components, such as microarrays, next-generation sequencing technologies, RNA interference, and epigenetic analysis using DNA methylation techniques and chromatin immunoprecipitation. To make sense of the wealth of data produced by these techniques, a bioinformatics chapter describes the use of analytical tools for comparing sequences of genes and proteins and identifying common expression patterns among sets of genes. Please take a look at our book preview site at molecularcloning.com. Building on thirty years of trust, reliability, and authority, the fourth edition of Molecular Cloning is the new gold standard--the one indispensable molecular biology laboratory manual and reference source.

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Beautiful Code O'Reilly Media

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How do the experts solve difficult problems in software development? In this unique and insightful book, leading computer scientists offer case studies that reveal how they found unusual, carefully designed solutions to high-profile projects. You will be able to look over the shoulder of major coding and design experts to see problems through their eyes. This is not simply another design patterns book, or another software engineering treatise on the right and wrong way to do things. The authors think aloud as they work through their project's architecture, the tradeoffs made in its construction, and when it was important to break rules. "Beautiful Code" is an opportunity for master coders to tell their story. All author royalties will be donated to Amnesty International. The book includes the following contributions: "Beautiful Brevity: Rob Pike's Regular Expression Matcher" by Brian Kernighan, Department of Computer Science, Princeton University; "Subversion's Delta Editor: Interface as Ontology" by Karl Fogel, editor of "QuestionCopyright.org", Co-founder of Cyclic Software, the first company offering commercial CVS support; "The Most Beautiful Code I Never Wrote" by Jon Bentley, Avaya Labs Research; "Finding Things" by Tim Bray, Director of Web Technologies at Sun Microsystems, co-inventor of XML 1.0; "Correct, Beautiful, Fast (In That Order): Lessons From Designing XML Validators" by Elliotte Rusty Harold, Computer Science Department at Polytechnic University, author of "Java I/O, Java Network Programming", and "XML in a Nutshell" (O'Reilly); and, "The Framework for Integrated Test: Beauty through Fragility" by Michael Feathers, consultant at Object Mentor, author of "Working Effectively with Legacy Code" (Prentice Hall). It also includes: "Beautiful Tests" by Alberto Savoia, Chief Technology Officer, Agitar Software Inc; "On-the-Fly Code Generation for Image Processing" by Charles Petzold, author "Programming Windows and Code: The Hidden Language of Computer Hardware and Software" (both Microsoft Press); "Top Down Operator Precedence" by Douglas Crockford, architect at Yahoo!Inc, Founder and CTO of State Software, where he discovered JSON; "Accelerating Population Count" by Henry Warren, currently works on the Blue Gene petaflop computer project Worked for IBM for 41 years; "Secure Communication: The Technology of Freedom" by Ashish Gulhati, Chief Developer of Neomailbox, an Internet privacy service Developer of Cryptonite, an OpenPGP-compatible secure webmail system; and, "Growing Beautiful Code in BioPerl" by Lincoln Stein, investigator at Cold Spring Harbor Laboratory - develops databases and user interfaces for the Human Genome Project using the Apache server and its module API.It also includes: "The Design of the Gene Sorter" by Jim Kent, Genome Bioinformatics Group, University of California Santa Cruz; "How Elegant Code Evolves With Hardware: The Case Of Gaussian Elimination" by Jack Dongarra, University Distinguished Professor of Computer Science in the Computer Science Department at the University of Tennessee, also distinguished Research Staff member in the Computer Science and Mathematics Division at Oak Ridge National Laboratory (ORNL) and Piotr Luszczek, Research Professor at the University of Tennessee; "Beautiful Numerics" by Adam Kolawa, co-founder and CEO of Parasoft; and, "The Linux Kernel Driver Model" by Greg Kroah-Hartman, SuSE Labs/Novell, Linux kernel maintainer for driver subsystems, author of "Linux Kernel in a Nutshell", co-author of "Linux Device Drivers, 3rd Edition" (O'Reilly).It also includes: "Another Level of Indirection" by Diomidis Spinellis, Associate Professor at the Department of Management Science and Technology at the Athens University of Economics and Business, Greece; "An Examination of Python's Dictionary Implementation" by Andrew Kuchling, longtime member of the Python development community, and a director of the Python Software Foundation; "Multi-Dimensional Iterators in NumPy" by Travis Oliphant, Assistant Professor in the Electrical and Computer Engineering Department at Brigham Young University; and, "A Highly Reliable Enterprise System for NASAs Mars Rover Mission" by Ronald Mak, co-founder and CTO of Willard & Lowe Systems, Inc, formerly a senior scientist at the Research Institute for Advanced Computer Science on contract to NASA Ames.It also includes: "ERP5: Designing for Maximum Adaptability" by Rogerio de Carvalho, researcher at the Federal Center for Technological Education of Campos (CEFET Campos), Brazil and Rafael Monnerat, IT Analyst at CEFET Campos, and an offshore consultant for Nexedi SARL; "A Spoonful of Sewage" by Bryan Cantrill, Distinguished Engineer at Sun Microsystems, where he has spent most of his career working on the Solaris kernel; "Distributed Programming with MapReduce" by Jeff Dean and Sanjay Ghemawat, Google Fellows in Google's Systems Infrastructure Group; "Beautiful Concurrency" by Simon Peyton Jones, Microsoft Research, key contributor to the design of the functional language Haskell, and lead designer of the Glasgow Haskell Compiler (GHC); and, "Syntactic Abstraction: The syntax-case expander" by Kent Dybvig, Developer of Chez Scheme and author of the Scheme Programming Language. It also includes: "Object-Oriented Patterns and a Framework for Networked Software" by William Otte, a Ph.D. student in the Department of Electrical Engineering and Computer Science (EECS) at Vanderbilt University and Doug Schmidt, Full Professor in the Electrical Engineering and Computer Science (EECS) Department, Associate Chair of the Computer Science and Engineering program, and a Senior Research Scientist at the Institute for Software Integrated Systems (ISIS) at Vanderbilt University; "Integrating Business Partners the RESTful Way" by Andrew Patzer, Director of the Bioinformatics Program at the Medical College of Wisconsin; and, "Beautiful Debugging" by Andreas Zeller, computer science professor at Saarland University, author of "Why Programs Fail: A Guide to Systematic Debugging" (Morgan Kaufman).It also includes: "Code That's Like an Essay" by Yukihiro Matsumoto, inventor of the Ruby language; "Designing Interfaces Under Extreme Constraints: the Stephen Hawking editor" by Arun Mehta, professor and chairman of the Computer Engineering department of JMIT, Radaur, Haryana, India; "Emacspeak: The Complete Audio Desktop" by TV Raman, Research Scientist at Google where he focuses on web applications; "Code in Motion" by Christopher Seiwald, founder and CTO of Perforce Software and Laura Wingerd, vice president of product technology at Perforce Software, author of "Practical Perforce" (O'Reilly); and, "Writing Programs for 'The Book'" by Brian Hayes who writes the Computing Science column in American Scientist magazine, author of "Infrastructure: A Field Guide to the Industrial Landscape"(W.W. Norton).

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Eight Day of Creation Cold Spring Harbor Laboratory Press,U.S.

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In this classic book, the distinguished science writer Horace Freeland Judson tells the story of the birth and early development of molecular biology in the US, the UK, and France. The fascinating story of the golden period from the revelation of the double helix of DNA to the cracking of the genetic code and first glimpses of gene regulation is told largely in the words of the main players, all of whom Judson interviewed extensively. The result is a book widely regarded as the best history of recent biological science yet published. This commemorative edition, honoring the memory of the author who died in 2011, contains essays by his daughter Olivia Judson, Matthew Meselson, and Mark Ptashne and an obituary by Jason Pontin. It contains all the content added to previous editions, including essays on some of the principal historical figures involved, such as Rosalind Franklin, and a sketch of the further development of molecular biology in the era of recombinant DNA.

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Hemoglobin and Its Diseases Cold Spring Harbor Laboratory Press,U.S.

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Hemoglobin is an iron-containing protein in red blood cells that transports oxygen to tissues throughout the body. The abundance, stability, and oxygen-carrying properties of hemoglobin can be altered by genetic mutations. More than 1000 hemoglobin disorde

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Epigenetics, Second Edition Cold Spring Harbor Laboratory Press,U.S.

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In many biological processes the regulation of gene expression involves epigenetic mechanisms. In this new edition of Epigenetics, 36 chapters written by experts in the field introduce and explain epigenetic effects from many perspectives. These include th

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RNA Worlds: New Tools for Deep Exploration Cold Spring Harbor Laboratory Press,U.S.

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RNA (ribonucleic acid) molecules drive much of cellular action. Messenger RNA (mRNA) relays genetic information from DNA to ribosomes to direct the formation of proteins. At the same time, noncoding RNAs act as enzymes, scaffolds, and regulatory molecules,

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Next-Generation DNA Sequencing Informatics, Second Edition Cold Spring Harbor Laboratory Press,U.S.

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Next-generation DNA sequencing (NGS) technology has revolutionized biomedical research, making genome and RNA sequencing an affordable and frequently used tool for a wide variety of research applications including variant (mutation) discovery, gene express

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Essentials of Glycobiology, Fourth Edition Cold Spring Harbor Laboratory Press,U.S.

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Hepatitis C Virus Cold Spring Harbor Laboratory Press,U.S.

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Hepatitis C infects 71 million people worldwide and there is currently no vaccine against the virus that causes the disease (HCV). This volume describes recent advances in our understanding of the biology of HCV and the consequences of infection, as well a

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James Darnell - RNA Cold Spring Harbor Laboratory Press,U.S.

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In RNA: Life's Indispensable Molecule, Jim Darnell provides a comprehensive and captivating account of RNA research, illuminated by his own life-long and celebrated engagement in the field. Darnell describes how scientists unraveled fundamental questions about the biochemical and genetic importance of RNA-how mRNAs are generated and used to produce proteins, how noncoding and catalytic RNAs mediate key cellular processes, and how RNA molecules likely initiated life on Earth. With a scope extending from the early 20th century to the present day, and with the clarity expected from an accomplished textbook author, he conveys the intellectual context in which these questions first arose and explains how the key experiments were structured and answers obtained. The book is geared towards scientists from the graduate level on up, and will particularly appeal to active investigators in RNA biology, educators of molecular biology and biochemistry, and science historians.

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Conscience and Courage Cold Spring Harbor Laboratory Press,U.S.

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Henri Termeer was one of the first of a pioneering group of business executives who built a disparate group of fledgling companies into a biotech industry that has driven decades of therapeutic innovation. During a 28-year career at Genzyme, including 26 y

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Essentials of Glycobiology, Third Edition Cold Spring Harbor Laboratory Press,U.S.

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Defined in the broadest sense, Glycobiology is the study of the structure, biosynthesis, biology, and evolution of saccharides (sugar chains or glycans) that are widely distributed in nature in all living life forms. Glycobiology is now one of the more rap

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